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Case Reports
. 2021 Jun;26(3):e12798.
doi: 10.1111/hel.12798. Epub 2021 Apr 5.

Transmission of Helicobacter pylori between a human and two dogs: A case report

Sanae Kubota-Aizawa  1 , Yasuo Matsubara  2 , Hideyuki Kanemoto  1 , Hitomi Mimuro  3   4 , Kazuyuki Uchida  5 , James Chambers  5 , Masaya Tsuboi  5 , Koichi Ohno  1 , Kenjiro Fukushima  1 , Naoya Kato  6 , Hiroshi Yotsuyanagi  2 , Hajime Tsujimoto  1
Affiliations
Case Reports

Transmission of Helicobacter pylori between a human and two dogs: A case report

Sanae Kubota-Aizawa et al. Helicobacter. 2021 Jun.

Abstract

Background: Whereas non-Helicobacter pylori helicobacters, which are frequently detected in the stomachs of dogs and cats as a source of zoonoses, have attracted considerable attention, the role of pets in H. pylori epidemiology is unclear. In our previous study, an H. pylori infection was detected in the stomach of a dog (Dog 1). Here, we investigated the H. pylori infection status in the female offspring of Dog 1 (Dog 2) and its owner within the same household.

Materials and methods: Biopsy specimens were obtained from the dog's owner and tested for H. pylori. DNA from gastric biopsy samples of Dog 1, gastric fluid sediment of Dog 2, and bacteria from the stomach of the owner was obtained, and Helicobacter genus- and species-specific PCRs were performed. Then, sequence analyses of the partial region of the ureAB gene were conducted.

Results: Samples from both dogs and the owner reacted positively in the genus-specific PCR and negative in the Helicobacter felis-, Helicobacter bizzozeronii-, and Helicobacter heilmannii sensu stricto-specific PCRs. All three samples also reacted positively in the H. pylori-specific PCR. Sequences of the partial ureAB gene from all subjects were identical.

Conclusions: The results suggested that the two dogs and their owner were infected with an identical H. pylori strain. This report is the first to demonstrate that H. pylori can be transmitted between humans and dogs. Further studies are required to investigate the risk factors for the transmission of H. pylori between humans and dogs from the perspective of preventive epidemiology.

Keywords: Helicobacter pylori; dogs; zoonosis.

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References

REFERENCES

    1. Baele M, Decostere A, Vandamme P, et al. Isolation and characterization of Helicobacter suis sp. nov. from pig stomachs. Int J Syst Evol Microbiol. 2008;58(Pt 6):1350-1358.
    1. Haesebrouck F, Pasmans F, Flahou B, et al. Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health. Clin Microbiol Rev. 2009;22(2):202-223.
    1. Boyanova L, Koumanova R, Lazarova E, Jelev C. Helicobacter pylori and Helicobacter heilmannii in children. A Bulgarian study. Diagn Microbiol Infect Dis. 2003;46(4):249-252.
    1. Debongnie JC, Donnay M, Mairesse J, Lamy V, Dekoninck X, Ramdani B. Gastric ulcers and Helicobacter heilmannii. Eur J Gastroenterol Hepatol. 1998;10(3):251-254.
    1. Dieterich C, Wiesel P, Neiger R, Blum A, Corthesy-Theulaz I. Presence of multiple "Helicobacter heilmannii" strains in an individual suffering from ulcers and in his two cats. J Clin Microbiol. 1998;36(5):1366-1370.

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