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Review
. 2021 May;68 Suppl 2(Suppl 2):e28473.
doi: 10.1002/pbc.28473.

Neuroblastoma

Christine Chung  1 , Tom Boterberg  2 , John Lucas  3 , Joseph Panoff  4 , Dominique Valteau-Couanet  5 , Barbara Hero  6 , Rochelle Bagatell  7 , Christine E Hill-Kayser  8
Affiliations
Review

Neuroblastoma

Christine Chung et al. Pediatr Blood Cancer. 2021 May.

Abstract

The survival of patients with high-risk neuroblastoma has improved significantly with the use of intensive multimodality treatment regimens, including chemotherapy, surgery, radiation therapy, myeloablative chemotherapy followed by stem cell rescue, and immunotherapy. This report summarizes the current treatment strategies used in the COG and SIOP for children with neuroblastoma. The improved global collaboration and the adoption of a uniform International Neuroblastoma Risk Group Staging System will help facilitate comparison of homogeneous pretreatment cohorts across clinical trials. Future research strategies regarding the indications for and dosages of radiation therapy to the primary and metastatic sites, and the integration of meta-iodobenzyl guanidine therapy into the multimodal treatment program, are discussed.

Keywords: MIBG; autologous stem cell rescue; chemotherapy; immunotherapy; neuroblastoma; radiation therapy; surgery.

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Conflict of interest statement

CONFLICT OF INTEREST: NONE

Figures

Figure 1:
Figure 1:
Multidisciplinary treatments and high dose chemotherapy and stem cell transplant strategies adopted in recent COG and European Protocols.
See this image and copyright information in PMC

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