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Review
. 2021 May:68 Suppl 2:e28700.
doi: 10.1002/pbc.28700.

Radiation therapy for infants with cancer

Colette J Shen  1 , Stephanie M Perkins  2 , Julie A Bradley  3 , Anita Mahajan  4 , Karen J Marcus  5
Affiliations
Review

Radiation therapy for infants with cancer

Colette J Shen et al. Pediatr Blood Cancer. 2021 May.

Abstract

The clinical outcomes for infants with malignant tumors are often worse than older children due to a combination of more biologically aggressive disease in some cases, and increased toxicity-or deintensification of therapies due to concern for toxicity-in others. Especially in infants and very young children, finding the appropriate balance between maximizing treatment efficacy while minimizing toxicity-in particular late side effects-is crucial. We review here the management of malignant tumors in infants and very young children, focusing on central nervous system (CNS) malignancies and rhabdomyosarcoma.

Keywords: brain tumors; cancer; chemotherapy; infants; late effects; radiation therapy; rhabdomyosarcoma; surgery.

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References

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