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. 2021 May:226:108720.
doi: 10.1016/j.clim.2021.108720. Epub 2021 Apr 2.

Serum levels of SARS-CoV-2 nucleocapsid antigen associate with inflammatory status and disease severity in COVID-19 patients

Francesco Perna  1 , Sara Bruzzaniti  2 , Erica Piemonte  3 , Valeria Maddaloni  4 , Lidia Atripaldi  5 , Silvia Sale  4 , Alessandro Sanduzzi  6 , Carmine Nicastro  4 , Nicola Pepe  4 , Maurizio Bifulco  3 , Giuseppe Matarese  7 , Mario Galgani  8 , Luigi Atripaldi  4
Affiliations

Serum levels of SARS-CoV-2 nucleocapsid antigen associate with inflammatory status and disease severity in COVID-19 patients

Francesco Perna et al. Clin Immunol. 2021 May.
No abstract available

Keywords: C-reactive protein; CLEIA; COVID-19; Inflammation; SARS-CoV-2 N-antigen; Serological assay.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Detection of SARS-CoV-2 N-antigen in the serum of COVID-19 patients associates with inflammation. (A) Bar histogram showing SARS-CoV-2 N-antigen concentrations (pg/mL) in serum of COVID-19 and healthy subjects (HS). ***P < 0.001 by Mann-Whitney U test. (B) SARS-CoV-2 N-antigen concentrations in COVID-19 patients from diagnosis (T0), to clinical improvement (T1) and until recovery (T2). *P < 0.05 T0 versus T1; §P < 0.01 T0 versus T2 by one-way ANOVA test, multiple comparison corrected for Bonferroni's test. (C) Bar histogram showing SARS-CoV-2 N-antigen concentration in COVID-19 patients stratified on the basis of serum CRP levels, as mild (≤ 5 mg/L), moderate (6–20 mg/L) and severe (21–80 mg/L) disease. ****P < 0.0001 by Mann-Whitney U test. Data are shown as mean ± S.E.M..
See this image and copyright information in PMC

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