Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2021 Apr 5;19(1):96.
doi: 10.1186/s12957-021-02207-4.

Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study

Inge van den Berg  1 , Robert R J Coebergh van den Braak  2 , Jeroen L A van Vugt  2 , Jan N M Ijzermans  2 , Stefan Buettner  2
Affiliations
Multicenter Study

Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study

Inge van den Berg et al. World J Surg Oncol. .

Erratum in

Abstract

Background: Colorectal cancer is the third most common type of cancer in the world. We characterize a cohort of patients who survived up to 5 years without recurrence and identify factors predicting the probability of cure.

Methods: We analyzed data of patients who underwent curative intent surgery for stage I-III CRC between 2007 and 2012 and who had had been included in a large multicenter study in the Netherlands. Cure was defined as 5-year survival without recurrence. Survival data were retrieved from a national registry.

Results: Analysis of data of 754 patients revealed a cure rate of 65% (n = 490). Patients with stage I disease and T1- and N0-tumor had the highest probability of cure (94%, 95% and 90%, respectively). Those with a T4-tumor or N2-tumor had the lowest probability of cure (62% and 50%, respectively). A peak in the mortality rate for older patients early in follow-up suggests early excess mortality as an explanation. A similar trend was observed for stage III disease, poor tumor grade, postoperative complications, sarcopenia, and R1 resections. Patients with stage III disease, poor tumor grade, postoperative complications, sarcopenia, and R1 resections show a similar trend for decrease in CSS deaths over time.

Conclusion: In the studied cohort, the probability of cure for patients with stage I-III CRC ranged from 50 to 95%. Even though most patients will be cured from CRC with standard therapy, standard therapy is insufficient for those with poor prognostic factors, such as high T- and N-stage and poor differentiation grade.

PubMed Disclaimer

Conflict of interest statement

The authors declare no potential conflicts of interest.

Figures

Fig. 1
Fig. 1
Current status and observed cure in study population
Fig. 2
Fig. 2
Kaplan-Meier curves on cancer-specific survival stratified by prognostic clinical factors. a Cancer-specific survival stratified by age. b Cancer-specific survival stratified by postoperative complications. c Cancer-specific survival stratified by preoperative CEA level. d Cancer-specific survival stratified by tumor location. e Cancer-specific survival stratified by tumor stage. f Cancer-specific survival stratified by T-stage. g Cancer-specific survival stratified by N-stage. h Cancer-specific survival stratified by tumor differentiation grade. i Cancer-specific survival stratified by neoadjuvant therapy. j Cancer-specific survival stratified by adjuvant therapy
Fig. 3
Fig. 3
Kaplan-Meier curve for cancer-specific survival for all patients undergoing resection for stage I–III colorectal cancer
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. The Global Cancer Observatory (GCO). https://gco.iarc.fr/. Accessed Aug 2020.
    1. Dienstmann R, Mason MJ, Sinicrope FA, Phipps AI, Tejpar S, Nesbakken A, Danielsen SA, Sveen A, Buchanan DD, Clendenning M, Rosty C, Bot B, Alberts SR, Milburn Jessup J, Lothe RA, Delorenzi M, Newcomb PA, Sargent D, Guinney J. Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study. Ann Oncol. 2017;28(5):1023–1031. doi: 10.1093/annonc/mdx052. - DOI - PMC - PubMed
    1. Karahalios A, English DR, Simpson JA. Weight change and risk of colorectal cancer: a systematic review and meta-analysis. Am J Epidemiol. 2015;181(11):832–845. doi: 10.1093/aje/kwu357. - DOI - PubMed
    1. Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K, International Agency for Research on Cancer Handbook Working G Body fatness and cancer--viewpoint of the IARC Working Group. N Engl J Med. 2016;375(8):794–798. doi: 10.1056/NEJMsr1606602. - DOI - PMC - PubMed
    1. Yuhara H, Steinmaus C, Cohen SE, Corley DA, Tei Y, Buffler PA. Is diabetes mellitus an independent risk factor for colon cancer and rectal cancer? Am J Gastroenterol. 2011;106(11):1911–1921. doi: 10.1038/ajg.2011.301. - DOI - PMC - PubMed

Publication types