Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Apr;2(4):e191.
doi: 10.1016/S2666-7568(21)00053-2. Epub 2021 Mar 31.

Tackling the pillars of ageing to fight COVID-19

Francesco Prattichizzo  1 , Jacopo Sabbatinelli  2 , Paola de Candia  1 , Fabiola Olivieri  2   3 , Antonio Ceriello  1
Affiliations
Comment

Tackling the pillars of ageing to fight COVID-19

Francesco Prattichizzo et al. Lancet Healthy Longev. 2021 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

AC discloses the following conflicts of interest: advisory board membership of Eli Lilly; consultancy with Roche Diagnostics, Eli Lilly, and Theras; lectures with Berlin Chemie, Eli Lilly, Novo Nordisk, and Roche Diagnostics; and a research grant with Mitsubishi. FP reports lecture fees from Berlin Chemie, outside the submitted work. All other authors declare no competing interests. This work has been supported by the Italian Ministry of Health—Ricerca Corrente to IRCCS MultiMedica.

Comment on

References

    1. Bonafè M, Prattichizzo F, Giuliani A, Storci G, Sabbatinelli J, Olivieri F. Inflamm-aging: why older men are the most susceptible to SARS-CoV-2 complicated outcomes. Cytokine Growth Factor Rev. 2020;53:33–37. - PMC - PubMed
    1. Bramante CT, Ingraham NE, Murray TA. Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis. Lancet Healthy Longev. 2021;2:e34–e41. - PMC - PubMed
    1. Campbell JM, Bellman SM, Stephenson MD, Lisy K. Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: a systematic review and meta-analysis. Ageing Res Rev. 2017;40:31–44. - PubMed
    1. American Federation for Aging Research The TAME trial. Targeting the biology of aging. Ushering a new era of interventions. 2021. https://www.afar.org/tame-trial
    1. Prattichizzo F, Giuliani A, Mensà E. Pleiotropic effects of metformin: shaping the microbiome to manage type 2 diabetes and postpone ageing. Ageing Res Rev. 2018;48:87–98. - PubMed