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Review
. 2021 Dec;53(1):567-575.
doi: 10.1080/07853890.2021.1908586.

Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature

Dengqin Zhu  1 , Doudou Tang  2 , Xiaoshan Chai  3 , Guangsen Zhang  1   4 , Yewei Wang  1   4
Affiliations
Review

Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature

Dengqin Zhu et al. Ann Med. 2021 Dec.

Abstract

Introduction: Acute leukemia (AL) occurring in pregnancy is extremely rare, and its treatment is a clinical dilemma.

Methods: We retrospectively reviewed the medical records of our hospital from 2010 to 2019.

Results: Twenty-one patients were diagnosed with AL during pregnancy. Of whom, eighteen had acute myeloid leukemia, and 3 had acute lymphoblastic leukemia. Six, eight and seven patients were diagnosed during the first, second, and third trimester, respectively. Six of the 21 patients experienced therapeutic abortion and 1 had spontaneous abortion, whereas 9 gave birth to healthy babies (4 through vaginal deliveries and 5 with Caesarean sections). Four babies had been exposed to chemotherapeutic agents, but no congenital malformations were observed. Sixteen patients received chemotherapy, while 4 patients died before chemotherapy and one was discharged after refusing chemotherapy. The complete remission rate of the 10 patients who began chemotherapy immediately after diagnosis was 80%, compared with 66.7% in the 6 patients who started chemotherapy after abortion or delivery. Three remain alive.

Conclusions: In general, initiation of chemotherapy as early as possible may increase the CR rate. Combined with literature data, we proposed that, for patients diagnosed in early and late stages of pregnancy (>30 weeks), elective termination or induced delivery before chemotherapy may be a good choice for better maternal (and fetal) outcome.KEY MESSAGESAcute leukaemia diagnosed in pregnancy is extremely rare, and its treatment is a clinical dilemma.In general, initiation of chemotherapy as early as possible may increase the CR rate.For patients who are diagnosed in the first trimester or late stage of pregnancy (>30 weeks), elective termination or induced delivery before starting chemotherapy may be a good choice for better maternal (and fetal) outcome.

Keywords: Acute leukaemia; acute lymphoblastic leukaemia; acute myeloid leukaemia; chemotherapy; pregnancy.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Proposed management of acute leukemia during pregnancy.
See this image and copyright information in PMC

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