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Comment
. 2021 Jun 22;144(5):e47.
doi: 10.1093/brain/awab070.

Reply: Guillain-Barré syndrome, SARS-CoV-2 and molecular mimicry and Ongoing challenges in unravelling the association between COVID-19 and Guillain-Barré syndrome and Unclear association between COVID-19 and Guillain-Barré syndrome and Currently available data regarding the potential association between COVID-19 and Guillain-Barré syndrome

Michael P Lunn  1   2 , Aisling C Carr  2 , Stephen Keddie  1   2 , Julia Pakpoor  3 , Menelaos Pipis  1   2 , Hugh J Willison  4
Affiliations
Comment

Reply: Guillain-Barré syndrome, SARS-CoV-2 and molecular mimicry and Ongoing challenges in unravelling the association between COVID-19 and Guillain-Barré syndrome and Unclear association between COVID-19 and Guillain-Barré syndrome and Currently available data regarding the potential association between COVID-19 and Guillain-Barré syndrome

Michael P Lunn et al. Brain. .
No abstract available

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Figures

Figure 1
Figure 1
Daily UK infections with COVID-19 by PCR (blue bars) and monthly cases of GBS. 2020 = red dotted line, 2019 = green dashed line, secondary y-axis. The graphs demonstrate no visible increase in GBS in the last quarter of 2020 with a rise in case numbers between 30% and 1000% more than in March/April. Note significant alterations in testing occurred in the UK in April 2020 resulting the subsequent enhanced detection of most symptomatic cases subsequently. Hospital admissions were 30% higher on 1 January 2021 than in April 2020. Sources: COVID cases (left axis, blue bars) https://coronavirus.data.gov.uk/details/cases; NHSE National Immunoglobulin Database courtesy MDSAS, Manchester, UK.
Figure 2
Figure 2
Forest plot of March April incidence rates per 100 000 people per year of GBS from four studies. Note the heterogeneity illustrated by I2 = 98% indicating that these series cannot be considered in meta-analysis or generate a reliable summary statistic. Box sizes illustrate the relative weight of the estimate displayed.
See this image and copyright information in PMC

Comment on

References

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    1. Lunn MP, Cornblath DR, Jacobs BC, et al. COVID-19 vaccine and Guillain-Barre syndrome: Let's not leap to associations. Brain. 2021;144:357-360. - PMC - PubMed
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    1. Vogrig A, Moritz CP, Camdessanché J-P, et al. Unclear association between COVID-19 and Guillain-Barré syndrome. Brain. 2021;awab068. doi:10.1093/brain/awab068 - PMC - PubMed
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