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Editorial
. 2021 Aug 2;23(8):1218-1219.
doi: 10.1093/neuonc/noab083.

Prognostication for meningiomas: H3K27me3 to the rescue?

Sandro Santagata  1   2   3   4 , Keith L Ligon  1   2   3   4
Affiliations
Editorial

Prognostication for meningiomas: H3K27me3 to the rescue?

Sandro Santagata et al. Neuro Oncol. .
No abstract available

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Comment on

  • H3K27me3 loss indicates an increased risk of recurrence in the Tübingen meningioma cohort.
    Behling F, Fodi C, Gepfner-Tuma I, Kaltenbach K, Renovanz M, Paulsen F, Skardelly M, Honegger J, Tatagiba M; International Consortium on Meningiomas; Schittenhelm J, Tabatabai G. Behling F, et al. Neuro Oncol. 2021 Aug 2;23(8):1273-1281. doi: 10.1093/neuonc/noaa303. Neuro Oncol. 2021. PMID: 33367841 Free PMC article.
  • Loss of H3K27me3 in meningiomas.
    Nassiri F, Wang JZ, Singh O, Karimi S, Dalcourt T, Ijad N, Pirouzmand N, Ng HK, Saladino A, Pollo B, Dimeco F, Yip S, Gao A, Aldape KD, Zadeh G; International Consortium on Meningiomas. Nassiri F, et al. Neuro Oncol. 2021 Aug 2;23(8):1282-1291. doi: 10.1093/neuonc/noab036. Neuro Oncol. 2021. PMID: 33970242 Free PMC article.

References

    1. Nassin F, Wang JZ, Singh O, et al. . Loss of H3K27me3 in meningiomas. Neuro Oncol. 2021;23(8):1282–1291. - PMC - PubMed
    1. Behling F, Fodi C, Gepfner-Tuma I, et al. . H3K27me3 loss indicates an increased risk of recurrence in the Tübingen meningioma cohort. Neuro Oncol. 2021;23(8):1273–1281. - PMC - PubMed
    1. Cleven AH, Sannaa GA, Briaire-de Bruijn I, et al. . Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival. Mod Pathol. 2016;29(6):582–590. - PMC - PubMed
    1. Venneti S, Santi M, Felicella MM, et al. . A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas. Acta Neuropathol. 2014;128(5):743–753. - PMC - PubMed
    1. Panwalkar P, Clark J, Ramaswamy V, et al. . Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome. Acta Neuropathol. 2017;134(5):705–714. - PMC - PubMed