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. 2021 Jun 10;384(23):2259-2261.
doi: 10.1056/NEJMc2103916. Epub 2021 Apr 6.

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

Nicole Doria-Rose  1 , Mehul S Suthar  2 , Mat Makowski  3 , Sarah O'Connell  4 , Adrian B McDermott  4 , Britta Flach  4 , Julie E Ledgerwood  4 , John R Mascola  4 , Barney S Graham  4 , Bob C Lin  4 , Sijy O'Dell  4 , Stephen D Schmidt  4 , Alicia T Widge  4 , Venkata-Viswanadh Edara  5 , Evan J Anderson  5 , Lilin Lai  5 , Katharine Floyd  5 , Nadine G Rouphael  5 , Veronika Zarnitsyna  5 , Paul C Roberts  4 , Mamodikoe Makhene  4 , Wendy Buchanan  4 , Catherine J Luke  4 , John H Beigel  4 , Lisa A Jackson  6 , Kathleen M Neuzil  7 , Hamilton Bennett  8 , Brett Leav  8 , Jim Albert  3 , Pratap Kunwar  3 ; mRNA-1273 Study Group
Collaborators, Affiliations

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

Nicole Doria-Rose et al. N Engl J Med. .

Erratum in

No abstract available

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Figures

Figure 1
Figure 1. Time Course of SARS-CoV-2 Antibody Binding and Neutralization Responses after mRNA-1273 Vaccination.
All the participants received 100 μg of mRNA-1273 on days 1 and 29, indicated by arrows. The numbers of participants in each age group with data available at day 209 are as follows: 18 to 55 years, 15 participants; 56 to 70 years, 9 participants; and 71 years or older, 9 participants. The titers shown are the binding to spike receptor–binding domain protein (the end-point dilution titer) assessed on enzyme-linked immunosorbent assay (ELISA) on days 1, 15, 29, 36, 43, 57, 119, and 209 (Panel A); the 50% inhibitory dilution (ID50) titer on pseudovirus neutralization assay on days 1, 15, 29, 36, 43, 57, 119, and 209 (Panel B); and the ID50 titer on the live-virus focus-reduction neutralization mNeonGreen test (FRNT-mNG) on days 1, 29, 43, 119, and 209 (Panel C). Lines show geometric mean titers for each age group; 𝙸 bars indicate 95% confidence intervals. The dashed line indicates the limit of detection for each assay.
See this image and copyright information in PMC

References

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