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doi: 10.1016/j.devcel.2021.03.016.
The spatial organization of cGAS-TREX1 interactions
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- PMID: 33823133
- DOI: 10.1016/j.devcel.2021.03.016
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Comment
The spatial organization of cGAS-TREX1 interactions
Dev Cell.
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Free article
Abstract
Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021) and Zhou et al. (2021), uncover new aspects of this important control mechanism.
Copyright © 2021. Published by Elsevier Inc.
Conflict of interest statement
Declaration of interests A.A. is a member of the scientific advisory board of IFM Therapeutics and the scientific co-founder of IFM Due.
Comment on
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cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.Mol Cell. 2021 Feb 18;81(4):739-755.e7. doi: 10.1016/j.molcel.2021.01.024. Mol Cell. 2021. PMID: 33606975 Free PMC article.
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ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD.Dev Cell. 2021 Apr 5;56(7):949-966. doi: 10.1016/j.devcel.2021.03.005. Epub 2021 Mar 24. Dev Cell. 2021. PMID: 33765438 Review.
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