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. 2021 Jul:108:1-3.
doi: 10.1016/j.ijid.2021.03.087. Epub 2021 Apr 3.

High-flow oxygen therapy in elderly patients infected with SARS-CoV2 with a contraindication for transfer to an intensive care unit: A preliminary report

Jean-Christophe Lagier  1 , Sophie Amrane  1 , Morgane Mailhe  1 , Marc Gainnier  2 , Sylvie Arlotto  3 , Stéphanie Gentile  3 , Didier Raoult  4
Affiliations

High-flow oxygen therapy in elderly patients infected with SARS-CoV2 with a contraindication for transfer to an intensive care unit: A preliminary report

Jean-Christophe Lagier et al. Int J Infect Dis. 2021 Jul.

Abstract

Objectives: In a conventional hospital ward, we used high-flow nasal oxygen (HFNO) to treat elderly COVID-19 patients noneligible for intensive care unit transfer.

Methods: This study was conducted in the Institut Hospitalo-Universitaire Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille (AP-HM), France. We used high-flow nasal oxygen (HFNO) in our conventional infectious disease ward from 15 September 2020 for elderly patients noneligible for intensive care unit transfer.

Results: Of the 44 patients (median age 83 years (57-94), mean: 80.25), 61.4% (27/44) were men. The median Charlson score was 7 (1-15). The median of the NEWS-2 score upon admission was 8 (3-11) and was 10 at the time of initiation of HFNO. The median PaO2/FiO2 ratio was 103 (71-151) prior to HNFO initiation. Among the 44 patients, 16 patients (36.4%) had been weaned from HFNO, and 28 patients had died (63.6%).

Conclusions: In this preliminary report, we observed that HFNO saved the lives of one-third of elderly COVID-19 patients who would have systematically died.

Keywords: COVID-19; Conventional hospital ward; Elderly patients; High-flow oxygen therapy; SARS-CoV2.

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