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. 2021 Apr;49(4):3000605211002960.
doi: 10.1177/03000605211002960.

Effect of supplemental dexmedetomidine in interventional embolism on cerebral oxygen metabolism in patients with intracranial aneurysms

Zhang Guo  1 , Weiwei Wang  1 , Dahua Xie  1 , Ruisheng Lin  1
Affiliations

Effect of supplemental dexmedetomidine in interventional embolism on cerebral oxygen metabolism in patients with intracranial aneurysms

Zhang Guo et al. J Int Med Res. 2021 Apr.

Abstract

Objective: To investigate the effect of supplemental dexmedetomidine in interventional embolism on cerebral oxygen metabolism in patients with intracranial aneurysms.

Methods: Ninety patients who underwent interventional embolism of intracranial aneurysms were equally divided into Group A and Group B. In Group A, dexmedetomidine was injected intravenously 10 minutes before inducing anesthesia, with a loading dose of 0.6 µg/kg followed by 0.4 µg/kg/hour. Group B received the same amount of normal saline by the same injection method. Heart rate (HR), mean arterial pressure (MAP), arterial-jugular venous oxygen difference [D(a-jv) (O2)], cerebral oxygen extraction [CE (O2)], and intraoperative propofol use were recorded before inducing anesthesia (T0) and at five time points thereafter.

Results: The amount of propofol in Group A was lower vs Group B. At all five time points after T0, HR, MAP, D(a-jv) (O2), and CE (O2) in Group A were significantly lower vs Group B, with significant differences for jugular venous oxygen saturation (SjvO2) and the oxygen content of the internal jugular vein (CjvO2) between the groups.

Conclusion: Dexmedetomidine resulted in less intraoperative propofol, lower D(a-jv) (O2) and CE (O2), and improved cerebral oxygen metabolism.

Keywords: Dexmedetomidine; anesthesia; arterial–jugular venous oxygen difference [D(a-jv) (O2)]; cerebral extraction of oxygen [CE (O2)]; intracranial aneurysm; propofol; surgery.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Flowchart of patients participating in the study. BMI, body mass index; ASA, American Society of Anesthesiologists; HR, heart rate; MAP, mean arterial pressure.
See this image and copyright information in PMC

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