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. 2021 Apr;49(4):3000605211006522.
doi: 10.1177/03000605211006522.

Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study

Yaqin Zhang  1 , Xiaotong Zhao  2 , Yongxiang Li  3 , Youmin Wang  2 , Mingwei Chen  2   4
Affiliations

Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study

Yaqin Zhang et al. J Int Med Res. 2021 Apr.

Abstract

Objective: To explore the relationship between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer (CRC) in the Chinese Han population.

Methods: rs2274907 A>T was assessed by PCR-restriction fragment length polymorphism analysis. Plasma omentin-1 expression from 358 patients with CRC and 286 healthy controls was analyzed by enzyme-linked immunosorbent assay. CRC and control groups were divided into subgroups according to the body mass index (BMI) threshold of 25 kg/m2.

Results: No significant differences were observed between CRC and control groups in terms of genotype or allele frequencies of rs2274907 A>T. Compared with individuals with BMI <25 kg/m2 and the rs2274907 TT genotype, those with AA+AT genotypes and BMI ≥25 kg/m2 had a 3.027-fold increased risk of CRC. A significant tendency toward a higher stage of colorectal adenocarcinomas and depth of invasion was observed in individuals with the rs2274907 AA genotype compared with other genotypes.

Conclusions: The omentin-1 gene rs2274907 A>T polymorphism does not seem to play a critical role in the development of CRC in the Chinese Han population, but an interaction between the rs2274907 A allele and BMI may increase the CRC risk. The rs2274907 AA genotype is a potential biomarker for CRC stage progression.

Keywords: Chinese Han; Omentin-1; biomarker; body mass index; colorectal cancer; genotype; rs2274907.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

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