Anti-SARS-CoV-2 RBD IgG responses in convalescent versus naïve BNT162b2 vaccine recipients

doi:10.1016/j.vaccine.2021.03.086

. 2021 Apr 28;39(18):2489-2490.

doi: 10.1016/j.vaccine.2021.03.086. Epub 2021 Mar 30.

Anti-SARS-CoV-2 RBD IgG responses in convalescent versus naïve BNT162b2 vaccine recipients

Lorenzo Azzi¹, Daniele Focosi², Francesco Dentali³, Andreina Baj⁴, Fabrizio Maggi⁵

Affiliations

¹ Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Varese, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
² North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy.
³ Department of Medicine and Surgery, University of Insubria, Varese, Italy; Department of Medicine, ASST dei Sette Laghi, Varese, Italy.
⁴ Department of Medicine and Surgery, University of Insubria, Varese, Italy; Laboratory of Microbiology, ASST dei Sette Laghi, Varese, Italy. Electronic address: andreina.baj@uninsubria.it.
⁵ Department of Medicine and Surgery, University of Insubria, Varese, Italy; Laboratory of Microbiology, ASST dei Sette Laghi, Varese, Italy.

PMID: 33824042
PMCID: PMC8009041
DOI: 10.1016/j.vaccine.2021.03.086

Anti-SARS-CoV-2 RBD IgG responses in convalescent versus naïve BNT162b2 vaccine recipients

Lorenzo Azzi et al. Vaccine. 2021.

. 2021 Apr 28;39(18):2489-2490.

doi: 10.1016/j.vaccine.2021.03.086. Epub 2021 Mar 30.

Authors

Lorenzo Azzi¹, Daniele Focosi², Francesco Dentali³, Andreina Baj⁴, Fabrizio Maggi⁵

Affiliations

¹ Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Varese, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
² North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy.
³ Department of Medicine and Surgery, University of Insubria, Varese, Italy; Department of Medicine, ASST dei Sette Laghi, Varese, Italy.
⁴ Department of Medicine and Surgery, University of Insubria, Varese, Italy; Laboratory of Microbiology, ASST dei Sette Laghi, Varese, Italy. Electronic address: andreina.baj@uninsubria.it.
⁵ Department of Medicine and Surgery, University of Insubria, Varese, Italy; Laboratory of Microbiology, ASST dei Sette Laghi, Varese, Italy.

PMID: 33824042
PMCID: PMC8009041
DOI: 10.1016/j.vaccine.2021.03.086

No abstract available

Keywords: BNT162b2; COVID-19; SARS-CoV-2; mRNA-1273.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

**Fig. 1**
Anti-S1/S2 IgG levels at the day of vaccination (t0), 14 days after the first dose (t1), and 14 days after the second dose (t2) of BNT162b2 vaccine in convalescent versus *naïve* vaccinees.

See this image and copyright information in PMC

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References

1. Polack F.P., Thomas S.J., Kitchin N., et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. New Engl J Med. 2020;383:2603–2615. - PMC - PubMed
1. Widge A.T., Rouphael N.G., Jackson L.A., et al. Durability of responses after SARS-CoV-2 mRNA-1273 vaccination. New Engl J Med. 2020;384(1):80–82. - PMC - PubMed
1. Ayoub HH, Chemaitelly H, Makhoul M, et al. Epidemiological impact of prioritizing SARS-CoV-2 vaccination by antibody status: mathematical modeling analyses. 2021; 2021.01.10.21249382. - PubMed
1. Bonelli F., Sarasini A., Zierold C., et al. Clinical and analytical performance of an automated serological test that identifies S1/S2-neutralizing IgG in COVID-19 patients semiquantitatively. J Clin Microbiol. 2020;58(9):e01224–e1320. - PMC - PubMed
1. WHO. SAGE roadmap for prioritizing uses of COVID19 vaccines in the context of limited supply. Version 1.1.; 2020.

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[1] Polack F.P., Thomas S.J., Kitchin N., et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. New Engl J Med. 2020;383:2603–2615. - PMC - PubMed

[2] Polack F.P., Thomas S.J., Kitchin N., et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. New Engl J Med. 2020;383:2603–2615. - PMC - PubMed

[3] Widge A.T., Rouphael N.G., Jackson L.A., et al. Durability of responses after SARS-CoV-2 mRNA-1273 vaccination. New Engl J Med. 2020;384(1):80–82. - PMC - PubMed

[4] Widge A.T., Rouphael N.G., Jackson L.A., et al. Durability of responses after SARS-CoV-2 mRNA-1273 vaccination. New Engl J Med. 2020;384(1):80–82. - PMC - PubMed

[5] Ayoub HH, Chemaitelly H, Makhoul M, et al. Epidemiological impact of prioritizing SARS-CoV-2 vaccination by antibody status: mathematical modeling analyses. 2021; 2021.01.10.21249382. - PubMed

[6] Ayoub HH, Chemaitelly H, Makhoul M, et al. Epidemiological impact of prioritizing SARS-CoV-2 vaccination by antibody status: mathematical modeling analyses. 2021; 2021.01.10.21249382. - PubMed

[7] Bonelli F., Sarasini A., Zierold C., et al. Clinical and analytical performance of an automated serological test that identifies S1/S2-neutralizing IgG in COVID-19 patients semiquantitatively. J Clin Microbiol. 2020;58(9):e01224–e1320. - PMC - PubMed

[8] Bonelli F., Sarasini A., Zierold C., et al. Clinical and analytical performance of an automated serological test that identifies S1/S2-neutralizing IgG in COVID-19 patients semiquantitatively. J Clin Microbiol. 2020;58(9):e01224–e1320. - PMC - PubMed

[9] WHO. SAGE roadmap for prioritizing uses of COVID19 vaccines in the context of limited supply. Version 1.1.; 2020.

[10] WHO. SAGE roadmap for prioritizing uses of COVID19 vaccines in the context of limited supply. Version 1.1.; 2020.

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Anti-SARS-CoV-2 RBD IgG responses in convalescent versus naïve BNT162b2 vaccine recipients

Affiliations

Anti-SARS-CoV-2 RBD IgG responses in convalescent versus naïve BNT162b2 vaccine recipients

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Conflict of interest statement

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