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. 2021 Jul;26(7):1322-1329.
doi: 10.1007/s10147-021-01904-0. Epub 2021 Apr 6.

Survival impact of adjuvant concurrent chemoradiotherapy after radical hysterectomy in FIGO stage IIIC1 cervical adenocarcinoma

Kazuhiro Suzuki  1 , Shoji Nagao  2 , Moyu Narita  1 , Hiroshi Nakazawa  1 , Takashi Shibutani  1 , Kasumi Yamamoto  1 , Tomoatsu Jimi  1 , Hiroko Yano  1 , Miho Kitai  1 , Takaya Shiozaki  1 , Kazuko Matsuoka  1 , Satoshi Yamaguchi  1
Affiliations

Survival impact of adjuvant concurrent chemoradiotherapy after radical hysterectomy in FIGO stage IIIC1 cervical adenocarcinoma

Kazuhiro Suzuki et al. Int J Clin Oncol. 2021 Jul.

Abstract

Background: We evaluated the survival effect of adjuvant concurrent chemoradiotherapy after radical hysterectomy in patients with clinical pelvic node-positive cervical adenocarcinoma.

Methods: Patients with pelvic node-positive cervical adenocarcinoma diagnosed between 2000 and 2016 at our institution were identified. Survival was compared between patients who underwent radical hysterectomy alone and those who received concurrent chemoradiotherapy as an adjuvant treatment. Survival analysis using log-rank test and Cox proportional hazards model was performed.

Results: We identified 80 patients who underwent radical hysterectomy for clinical pelvic node-positive cervical adenocarcinoma; of these, four with pathological pelvic node-negative adenocarcinoma were excluded. Of the 76 patients, 27 underwent radical hysterectomy alone and 49 received radical hysterectomy followed by concurrent chemoradiotherapy. With a median follow-up of 53 months, the 5-year overall survival rate was 51.0% in patients who underwent radical hysterectomy alone versus 53.0% in patients who received additional concurrent chemoradiotherapy (log-rank p = 0.455).

Conclusion: The addition of concurrent chemoradiotherapy after radical hysterectomy did not significantly improve survival among patients with pelvic node-positive cervical adenocarcinoma. More appropriate treatment strategies are needed to improve the survival outcomes of these patients.

Keywords: Adenocarcinoma; Cervical cancer; Concurrent chemoradiotherapy; Pelvic lymph nodes; Radical hysterectomy.

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