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Review
. 2021 Jul;35(7):e22784.
doi: 10.1002/jbt.22784. Epub 2021 Apr 7.

Strategic targeting of non-small-cell lung cancer utilizing genetic material-based delivery platforms of nanotechnology

Swati Chaudhary  1 , Amit Singh  2   3 , Pankaj Kumar  2   3 , Mahima Kaushik  3
Affiliations
Review

Strategic targeting of non-small-cell lung cancer utilizing genetic material-based delivery platforms of nanotechnology

Swati Chaudhary et al. J Biochem Mol Toxicol. 2021 Jul.

Abstract

Several limitations of conventional cancer treatment such as non-specific targeting, solubility problems, and ineffective entry of chemotherapeutics into cancer cells can be overcome by using nanotechnology targeted drug delivery systems. Some combinations of biomolecules and nanoparticles have proven to be excellent therapeutics for Non-small cell lung cancer (NSCLC) in the last decades. Targeted gene delivery has shown in vivo as well as in vitro promising results with therapeutic efficacy. Gene therapy has shown enhanced transfection efficiency and better targeting potential on several NSCLC cell lines. Still, there are several challenges in nanoparticle-mediated gene therapy, which include stability of biomolecules and nanoparticles during delivery, managing their biodistribution, and reducing the possible cytotoxic effects of the nanoparticles, which need to be solved before clinical trials. Evaluation of therapeutic efficacy of biomolecules and nanoparticle combination in gene therapy must be established to expand the application of nano-gene therapy in cancer treatment.

Keywords: gene therapy; lung cancer; lung cancer mutations; nanotechnology based drug delivery; non-small-cell lung cancer.

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