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Review
. 2021 Aug;113(8):329-343.
doi: 10.1111/boc.202000148. Epub 2021 Apr 30.

Remodelling of membrane tubules by the actin cytoskeleton

Antoine Allard  1   2   3   4 , Rogério Lopes Dos Santos  1 , Clément Campillo  1
Affiliations
Review

Remodelling of membrane tubules by the actin cytoskeleton

Antoine Allard et al. Biol Cell. 2021 Aug.

Abstract

Inside living cells, the remodelling of membrane tubules by actomyosin networks is crucial for processes such as intracellular trafficking or organelle reshaping. In this review, we first present various in vivo situations in which actin affects membrane tubule remodelling, then we recall some results on force production by actin dynamics and on membrane tubules physics. Finally, we show that our knowledge of the underlying mechanisms by which actomyosin dynamics affect tubule morphology has recently been moved forward. This is thanks to in vitro experiments that mimic cellular membranes and actin dynamics and allow deciphering the physics of tubule remodelling in biochemically controlled conditions, and shed new light on tubule shape regulation.

Keywords: Actin; Membrane; Tubule; Vesicle trafficking.

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References

    1. Aghamohammadzadeh, S. and Ayscough, K. R. (2009). Differential requirements for actin during yeast and mammalian endocytosis. Nat. Cell Biol., 11(8), 1039-1042
    1. Akamatsu, M., Vasan, R., Serwas, D., Ferrin, M. A., Rangamani, P. and Drubin, D. G. (2020). Princi- ples of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis. Elife, 9
    1. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P. (2002). Molecular Biology of the Cell. New York: Garland Science
    1. Allain, J.-M., Storm, C., Roux, A., Amar, M. B. and Joanny, J.-F. (2004). Fission of a multiphase membrane tube. Phys. Rev. Lett., 93(15), 158104
    1. Allard, A., Valentino, F., Sykes, C., Betz, T. and Campillo, C. (2020a). Fluctuations of a membrane nanotube covered with an actin sleeve. Phys. Rev. E, 102:052402. https://doi.org/10.1103/Phys-RevE.102.052402

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