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Comment
. 2021 Apr 6;33(4):702-704.
doi: 10.1016/j.cmet.2021.03.010.

Pancreatic β cells put the glutamine engine in reverse

Evan C Lien  1 , Matthew G Vander Heiden  2
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Pancreatic β cells put the glutamine engine in reverse

Evan C Lien et al. Cell Metab. .
Free article

Abstract

The metabolism of nutrients other than glucose influences insulin secretion by pancreatic β cells, but the mechanisms involved are incompletely understood. In this issue of Cell Metabolism, Zhang et al. (2020) report that reductive glutamine metabolism generates cytosolic NADPH to promote insulin secretion by β cells.

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Conflict of interest statement

Declaration of interests M.G.V.H. discloses that he is on the scientific advisory board for Agios Pharmaceuticals, Aeglea Biotherapeutics, iTeos Therapeutics, Faeth Therapeutics, and Auron Therapeutics.

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