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Comment
. 2021 Jun;18(6):387.
doi: 10.1038/s41569-021-00550-3.

Preventing cardiac damage in patients with COVID-19

Andrew Robson  1
Affiliations
Comment

Preventing cardiac damage in patients with COVID-19

Andrew Robson. Nat Rev Cardiol. 2021 Jun.

Abstract

A cardiac organoid approach combined with phosphoproteomics and single nuclei RNA-sequencing identifies bromodomain and extraterminal family inhibitors as promising candidates to prevent COVID-19 mediated cardiac damage.

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Figures

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Comment on

  • BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
    Mills RJ, Humphrey SJ, Fortuna PRJ, Lor M, Foster SR, Quaife-Ryan GA, Johnston RL, Dumenil T, Bishop C, Rudraraju R, Rawle DJ, Le T, Zhao W, Lee L, Mackenzie-Kludas C, Mehdiabadi NR, Halliday C, Gilham D, Fu L, Nicholls SJ, Johansson J, Sweeney M, Wong NCW, Kulikowski E, Sokolowski KA, Tse BWC, Devilée L, Voges HK, Reynolds LT, Krumeich S, Mathieson E, Abu-Bonsrah D, Karavendzas K, Griffen B, Titmarsh D, Elliott DA, McMahon J, Suhrbier A, Subbarao K, Porrello ER, Smyth MJ, Engwerda CR, MacDonald KPA, Bald T, James DE, Hudson JE. Mills RJ, et al. Cell. 2021 Apr 15;184(8):2167-2182.e22. doi: 10.1016/j.cell.2021.03.026. Epub 2021 Mar 16. Cell. 2021. PMID: 33811809 Free PMC article.

References

Original article

    1. Mills RJ, et al. BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection. Cell. 2021 doi: 10.1016/j.cell.2021.03.026. - DOI - PMC - PubMed

Related article

    1. Nishiga M, et al. COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives. Nat. Rev. Cardiol. 2020;17:543–558. doi: 10.1038/s41569-020-0413-9. - DOI - PMC - PubMed