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Meta-Analysis
. 2021 Mar 22:12:643420.
doi: 10.3389/fimmu.2021.643420. eCollection 2021.

Meta-Analysis: Randomized Trials of Lactobacillus plantarum on Immune Regulation Over the Last Decades

Wei Zhao  1   2   3 , Chuantao Peng  1   2   3   4 , Hafiz Arbab Sakandar  1   2   3 , Lai-Yu Kwok  1   2   3 , Wenyi Zhang  1   2   3
Affiliations
Meta-Analysis

Meta-Analysis: Randomized Trials of Lactobacillus plantarum on Immune Regulation Over the Last Decades

Wei Zhao et al. Front Immunol. .

Abstract

Lactobacillus (L.) plantarum strains, belong to lactic acid bacteria group, are considered indispensable probiotics. Here, we performed meta-analysis to evaluate the regulatory effects of L. plantarum on the immunity during clinical trials. This meta-analysis was conducted by searching across four most common literature databases, namely, Cochrane Central Register of Controlled Trials, Web of Science, Embase, and PubMed. Clinical trial articles that met the inclusion and exclusion criteria were analyzed by Review Manager (version 5.3). p-value < 0.05 of the total effect was considered statistically significant. Finally, total of 677 references were retrieved, among which six references and 18 randomized controlled trials were included in the meta-analysis. The mean differences observed at 95% confidence interval: interleukin (IL)-4, -0.48 pg/mL (-0.79 to -0.17; p < 0.05); IL-10, 9.88 pg/mL (6.52 to 13.2; p < 0.05); tumor necrosis factor (TNF)-α, -2.34 pg/mL (-3.5 to -1.19; p < 0.05); interferon (IFN)-γ, -0.99 pg/mL (-1.56 to -0.41; p < 0.05). Therefore, meta-analysis results suggested that L. plantarum could promote host immunity by regulating pro-inflammatory and anti-inflammatory cytokines.

Keywords: IFN-γ; IL-10; IL-4; Lactobacillus plantarum; TNF-α; immunity; meta-analysis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the meta-analysis.
Figure 2
Figure 2
Forest plot of effect of Lactobacillus plantarum on IL-4. SD, standard deviation; Total, sample size of each group; Mean Difference, the mean value of the experimental group minus that of the control; 95% CI, 95% confidence intervals.
Figure 3
Figure 3
Forest plot of effect of Lactobacillus plantarum on IL-10. SD, standard deviation; Total, sample size of each group; Mean Difference, the mean value of the experimental group minus that of the control; 95% CI, 95% confidence intervals.
Figure 4
Figure 4
Forest plot of effect of Lactobacillus plantarum on TNF-α. SD, standard deviation; Total, sample size of each group; Mean Difference, the mean value of the experimental group minus that of the control; 95% CI, 95% confidence intervals.
Figure 5
Figure 5
Forest plot of effect of Lactobacillus plantarum on IFN-γ. SD, standard deviation; Total, sample size of each group; Mean Difference, the mean value of the experimental group minus that of the control; 95% CI, 95% confidence intervals.
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