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Review
. 2022 Jan;156(1):3-9.
doi: 10.1002/ijgo.13698. Epub 2021 Apr 21.

Preservation of female fertility: The current therapeutic strategy

Laurie Henry  1   2 , Soraya Labied  1 , Caroline Jouan  1 , Michelle Nisolle  1   2
Affiliations
Free article
Review

Preservation of female fertility: The current therapeutic strategy

Laurie Henry et al. Int J Gynaecol Obstet. 2022 Jan.
Free article

Abstract

Background: Preservation of female fertility is a relatively new field in medicine that has grown very rapidly in recent decades. At the beginning, embryo freezing remained the most effective technique. Thereafter, cryopreservation of oocytes and ovarian tissue was considered a secure tool in human fertility preservation. Storage of cortical ovarian tissue is moreover relevant for children, prepubertal girls, and adult patients who cannot benefit from cryopreservation of oocytes.

Objective: To analyze and review recent and relevant scientific literature on medical and social reasons for preservation of fertility.

Methods: The review was conducted based on articles identified from PubMed databases using keywords.

Main results: Oocyte vitrification allows women to preserve their fertility without the need for fertilization. Nowadays, thousands of healthy children have been born from this procedure. Occurrence of pregnancy depends on two main factors: the number of mature oocytes in storage and the age of the patient at the time of vitrification. Numerous adaptations have been developed to suit the ovarian stimulation regiments to patients with cancer. In young prepubertal girls, freezing of ovarian tissue remains the best and only option.

Conclusion: Oocyte vitrification therefore appears to be the gold standard technique of preserving fertility in young women.

Keywords: fertility preservation; oocyte vitrification; ovarian stimulation; ovarian tissue; pregnancy.

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References

REFERENCES

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67:7-30.
    1. Lee JL, Schover LR, Partridge AH, et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol. 2006;24:2917-2931.
    1. Wallace WH, Anderson RA, Irvine DS. Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol. 2005;6:209-218.
    1. Silvestris E, Dellino M, Cafforio P, Paradiso AV, Cormio G, D’Oronzo S. Breast cancer: an update on treatment-related infertility. J Cancer Res Clin Oncol. 2020;146:647-657.
    1. Mariani S, Chiloiro G, Villa P, et al. Fertility preservation in chemo-radiotherapy for rectal cancer: a combined approach. Clin Transl Radiat Oncol. 2019;19:77-79.

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