Computer-generated rotation analyses reveal a key three-dimensional feature of the nucleus of the solitary tract

Abstract

The dendritic processes of neurons within the nucleus of the solitary tract are oriented in the horizontal plane and often extend unusually long distances along the long axis of the brainstem. This preferred orientation is not predictable from a knowledge of the cytoarchitectonic organization of their somata within the various subnuclei of the nucleus of the solitary tract. Incoming peripheral afferent fibers, their collaterals and end-terminal ramifications are also oriented in the horizontal plane and are in alignment with the dendrites of second order neurons. These features enable single neurons to be influenced by a variety of widely distributed inputs that are related to vital autonomic functions and ingestional behavior.