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. 2021 Nov;39(10):789-796.
doi: 10.1080/07357907.2021.1913502. Epub 2021 Sep 27.

Real-World Incidence and Management of Immune-Related Adverse Events from Immune Checkpoint Inhibitors: Retrospective Claims-Based Analysis

Victoria T Brown  1 , Dana Drzayich Antol  1 , Patrick N Racsa  1 , Melea A Ward  1 , Jarushka Naidoo  2   3
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Real-World Incidence and Management of Immune-Related Adverse Events from Immune Checkpoint Inhibitors: Retrospective Claims-Based Analysis

Victoria T Brown et al. Cancer Invest. 2021 Nov.

Abstract

Purpose: We assessed real-world spectrum and patterns of irAEs for patients treated with anti-PD(L)1 ICIs.

Methods: irAEs were defined using medical and pharmacy claims for patients enrolled in a Medicare Advantage Prescription Drug plan who initiated treatment with anti-PD(L)-1 and received ≥ 1 dose of therapy between 1 September 2014 and 28 February 2018.

Results: Treatment was discontinued for 46.6% of patients, and withheld and subsequently restarted for 10.3%. While toxicity profiles did not differ by age, RiskRx-V co-morbidity index was higher in patients with irAEs.

Conclusion: These data underscore the needs for tailored irAE diagnostic and management pathways.

Keywords: Therapy; cancer in the elderly; treatment.

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