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. 2021 Dec;33(12):e14159.
doi: 10.1111/nmo.14159. Epub 2021 Apr 8.

Greater intolerance to uncertainty predicts poorer quality of life in adults with cyclic vomiting syndrome

David J Levinthal  1 , Stephanie Romutis  1 , Ajai Rajalaban  2 , Vishnu C S Kumar  3 , Robert Feldman  4 , Andrew D Althouse  4 , Thangam Venkatesan  5
Affiliations

Greater intolerance to uncertainty predicts poorer quality of life in adults with cyclic vomiting syndrome

David J Levinthal et al. Neurogastroenterol Motil. 2021 Dec.

Abstract

Background: Cyclic vomiting syndrome (CVS) is an idiopathic disorder of gut-brain interaction characterized by recurrent bouts of nausea and vomiting. Although CVS negatively impacts quality of life (QOL), the determinants of impaired QOL among adult CVS sufferers are not fully understood. The unpredictability of CVS attacks may generate anticipatory anxiety and worsen quality of life in a substantial proportion of patients with CVS. Intolerance to uncertainty (IU) is a cognitive trait in which individuals experience distress when faced with unpredictable situations, particularly those with potentially negative consequences. Higher trait IU is a well-established vulnerability factor linked to the development of multiple psychiatric conditions, including anxiety. However, the extent to which higher IU is associated with impaired QOL in adults with CVS is not known.

Methods: To explore this issue, we surveyed 118 adult CVS patients and obtained demographic information, clinical features, reported healthcare utilization, and standardized assessments of IU, anxiety and panic, and QOL.

Key results: Adult CVS patients with higher IU did not report a greater frequency of CVS attacks or overall CVS-related healthcare utilization than those with lower IU. Yet, this group demonstrated substantially poorer physical and mental health-related QOL and higher rates of anxiety-spectrum disorders.

Conclusions & inferences: Higher degrees of IU are associated with increased anxiety and reduced QOL in patients with CVS. IU is a malleable cognitive trait that can be targeted by cognitive behavioral therapy (CBT). Our results suggest that some CVS patients may benefit from non-pharmacologic therapies such as CBT.

Keywords: anxiety; cyclic vomiting syndrome; healthcare utilization; intolerance to uncertainty; quality of life.

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References

REFERENCES

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    1. Levinthal DJ. The cyclic vomiting syndrome threshold: a framework for understanding pathogenesis and predicting successful treatments. Clin Transl Gastroenterol. 2016;7:e198.
    1. Venkatesan T, Prieto T, Barboi A, et al. Autonomic nerve function in adults with cyclic vomiting syndrome: a prospective study. Neurogastroenterol Motil. 2010;22(12):1303-7 e339.
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Supplementary concepts