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. 2021 Dec 1;190(12):2503-2510.
doi: 10.1093/aje/kwab096.

Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study

Jinlei Li, Prajakta Joshi, Ting Fang Alvin Ang, Chunyu Liu, Sanford Auerbach, Sherral Devine, Rhoda Au

Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study

Jinlei Li et al. Am J Epidemiol. .

Abstract

Growing evidence relates body mass index (BMI) to poorer health outcomes; however, results across studies associating BMI and dementia are conflicting. A total of 3,632 Framingham Offspring participants aged 20 to 60 years at their second health examination (1979-1983) were included in this study, with 190 cases of incident dementia identified by 2017. Cox proportional hazards regression models were fitted to investigate the association of BMI at each of their 8 exams as a baseline for dementia risk and the associations between obesity and dementia across age groups. Spline models were fitted to investigate nonlinear associations between BMI and dementia. Each 1-unit increase in BMI at ages 40-49 years was associated with higher risk of dementia, but with lower risk after age 70 years. Obesity at ages 40-49 years was associated with higher risk of dementia. Overall, the relationship between BMI and dementia risk was heterogeneous across the adult age range. Monitoring BMI at different ages might mediate risk for dementia across an individual's lifetime.

Keywords: body mass index; dementia; obesity.

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Figures

Figure 1
Figure 1
Hazard ratios (HRs) of dementia according to body mass index (BMI) measured at each examination in the Framingham Offspring Cohort, Massachusetts, 1979–2014. CI, confidence interval.
Figure 2
Figure 2
Association between body mass index (BMI) and dementia, allowing for nonlinearity in the Framingham Offspring Cohort, Massachusetts, 1979–2017. A) Ages 40–49 years; B) ages 50–59 years; C) ages 60–69 years; D) ages ≥70 years).
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References

    1. World Health Organization . 10 facts on dementia. https://www.who.int/features/factfiles/dementia/dementia_facts/en/. Accessed July 19, 2021.
    1. Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413–446. - PMC - PubMed
    1. Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects), Lu Y, Hajifathalian K, et al. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants. Lancet. 2014;383(9921):970–983. - PMC - PubMed
    1. Albanese E, Launer LJ, Egger M, et al. Body mass index in midlife and dementia: systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies. Alzheimers Dement (Amst). 2017;8:165–178. - PMC - PubMed
    1. Gorospe EC, Dave JK. The risk of dementia with increased body mass index. Age Ageing. 2007;36(1):23–29. - PubMed

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