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Review
. 2021 May;123(6):1441-1448.
doi: 10.1002/jso.26365.

Neoadjuvant therapy for pancreas cancer: Global perspective and optimal care pathways in low to middle-income countries

Senthil J Rajappa  1 , Rakesh Pinninti  1 , Chandrakanth Are  2
Affiliations
Review

Neoadjuvant therapy for pancreas cancer: Global perspective and optimal care pathways in low to middle-income countries

Senthil J Rajappa et al. J Surg Oncol. 2021 May.

Abstract

Surgery remains the only curative intent treatment modality for localized pancreatic adenocarcinoma. Even in those who can undergo successful margin negative resection, the ability to deliver adjuvant chemotherapy is suboptimal for various reasons, resulting in poor outcomes. The delivery of "standard of care" intensive modern neoadjuvant therapies can be challenging in low to-middle-income countries (LMICs) with limited resource. This article reviews the constraints in delivering neoadjuvant therapies in LMICs and strategies to improve its implementation.

Keywords: borderline resectable; global perspective; low to middle income countries; neoadjuvant therapy; pancreatic cancer.

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