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. 2021 Sep 1;106(9):2499-2501.
doi: 10.3324/haematol.2021.278389.

Heritability and association with distinct genetic loci of erythropoietin levels in the general population

Tanguy Corre  1 , Belen Ponte  2 , Edward Pivin  3 , Menno Pruijm  4 , Daniel Ackermann  5 , Georg Ehret  6 , Katharina Spanaus  7 , Murielle Bochud  8 , Roland H Wenger  9
Affiliations

Heritability and association with distinct genetic loci of erythropoietin levels in the general population

Tanguy Corre et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Genome-wide association studies of erythropoietin plasma levels in the SKIPOGH cohort. (A) Histogram distribution of the mean values of duplicate erythropoietin (Epo) measurements in the blood plasma of 1,006 participants. (B) Correlation between Epo and hemoglobin (Hb) levels in the SKIPOGH cohort. (C) Manhattan plot showing the –log10 (P-value) of the association between Epo plasma levels and 6.4x106 single-nucleotide polymorphisms (SNP) in 872 samples following correction for sex, age and center. The blue line shows the indicative suggestive threshold of P<10–5. Markers are ranked by chromosome and positions. The green dot on chromosome 6 shows the top SNP at the HBS1L-MYB locus, and the green dot on chromosome 15 shows the top SNP at the MAP2K5-SKOR1-PIAS1 locus. (D) Region around the top SNP rs413451 in the MAP2K5-SKOR1-PIAS1 locus. (E) Region around the top SNP rs9402685 in the HBS1L-MYB intergenic locus which is the reference SNP found in our study. SKIPOGH: Swiss Kidney Project on Genes in Hypertension.
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References

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