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Comment
. 2021 Apr 9;372(6538):eabf2022.
doi: 10.1126/science.abf2022.

Comment on "Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression"

Jasper B J Kamphuis #  1 , William P M Worrall #  1 , Julien Stackowicz  2   3 , Aurélie Mougel  1 , Emilie Mauré  1 , Eva Conde  2   3 , Pierre Bruhns  2 , Laurent Guilleminault  1   4 , Nicolas Gaudenzio  5 , Jinmiao Chen  6 , Rebecca Gentek  7 , Laurent L Reber  8   2
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Comment on "Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression"

Jasper B J Kamphuis et al. Science. .
Free article

Abstract

Taniguchi et al (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing the immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence that the anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about the validity of some of the conclusions.

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