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Review
. 2021 May 1;16(3):133-140.
doi: 10.1097/COH.0000000000000677.

Frailty: the current challenge for aging people with HIV

Julian Falutz  1 , Fátima Brañas  2 , Kristine M Erlandson  3
Affiliations
Review

Frailty: the current challenge for aging people with HIV

Julian Falutz et al. Curr Opin HIV AIDS. .

Abstract

Purpose of review: Older adults account for the majority of people with HIV (PWH) in high-income countries and have increasingly complex clinical profiles related to premature aging. Frailty is an important geriatric syndrome affecting a minority of PHW. Frailty negatively affects PHW's clinical status and quality of life. This review will update care providers on the current state of frailty that limits the healthspan of PWH.

Recent findings: Ongoing low-level HIV replication in treated PWH leads to immune activation and chronic inflammation contributing to the destabilization of normally autoregulated physiologic systems in response to environmental and biologic challenges characteristic of frailty. Understanding these underlying mechanisms will determine potential intervention options. Potentially reversible risk factors that promote progression to and reversion from the dynamic state of frailty are being studied and will help prevent frailty. Simple assessment tools and treatment strategies for frailty are being adapted for aging PWH.

Summary: Insight into underlying biologic mechanisms and adapting proven geriatric principles of interdisciplinary care will inform the healthy aging of PWH.

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References

    1. Centers for Disease Control and Prevention. HIV Surveillance Report. https://www.cdc.gov/hiv/pdf/library/reports/surveillance/cdc-hiv-surveil... .
    1. Smit M, Brinkman K, Geerlings S, et al. Future challenges for clinical care of an ageing population infected with HIV: a modelling study. Lancet Infect Dis 2015; 15:810–818.
    1. Pathai S, Bajillan H, Landay AL, et al. Is HIV a model of accelerated or accentuated aging? J Gerontol A Biol Sci Med Sci 2014; 69:833–842.
    1. Fulop T, Larbi A, Witkowski JM, et al. Aging, frailty and age-related diseases. Biogerontology 2010; 11:547–563.
    1. Greene M, Covinsky KE, Valcour V, et al. Geriatric syndromes in older HIV-infected adults. J Acquir Immune Defic Syndr 2015; 69:161–167.