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Comment
. 2021 Mar 23:15:645694.
doi: 10.3389/fnins.2021.645694. eCollection 2021.

Commentary: Urinary Neopterin, a New Marker of the Neuroinflammatory Status in Amyotrophic Lateral Sclerosis

Gisele Espíndola  1   2   3 , Débora da Luz Scheffer  1 , Alexandra Latini  1
Affiliations
Comment

Commentary: Urinary Neopterin, a New Marker of the Neuroinflammatory Status in Amyotrophic Lateral Sclerosis

Gisele Espíndola et al. Front Neurosci. .
No abstract available

Keywords: amyotrophic lateral sclerosis; biomarkers; inflammation; neurodegenerative diseases; urine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Levels of neopterin in the urine of healthy controls grouped by age (A) or age and sex (B). Neopterin levels were assessed in urine samples collected in the morning with a minimum of 2 h retention in a collector plastic cup. Neopterin quantification was performed by liquid chromatography coupled with fluorescent detection as previously reported by our group (Scheffer et al., 2019). Graph was generated with GraphPad Software version 9.
See this image and copyright information in PMC

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References

    1. Brooks B. R. (1994). El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. J. Neurol. Sci. 124, 96–107. 10.1016/0022-510X(94)90191-0 - DOI - PubMed
    1. de Carvalho M., Dengler R., Eisen A., England J. D., Kaji R., Kimura J., et al. . (2008). Electrodiagnostic criteria for diagnosis of ALS. Clin. Neurophysiol. 119, 497–503. 10.1016/j.clinph.2007.09.143 - DOI - PubMed
    1. de Paula Martins R., Ghisoni K., Lim C. K., Aguiar A. S., Guillemin G. J., Latini A., et al. . (2018). Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes. Free Radic. Biol. Med. 115, 371–382. 10.1016/j.freeradbiomed.2017.11.022 - DOI - PubMed
    1. Fuchs D., Chiodi F., Albert J., Asjö B., Hagberg L., Hausen A., et al. . (1989). Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1. Aids 3, 285–288. 10.1097/00002030-198905000-00006 - DOI - PubMed
    1. Ghisoni K., Aguiar A. S., de Oliveira P. A., Matheus F. C., Gabach L., Perez M., et al. . (2016). Neopterin acts as an endogenous cognitive enhancer. Brain. Behav. Immun. 56, 156–164. 10.1016/j.bbi.2016.02.019 - DOI - PubMed

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