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Review
. 2021 Mar 23:12:648031.
doi: 10.3389/fneur.2021.648031. eCollection 2021.

Paroxysmal Genetic Movement Disorders and Epilepsy

Claudio M de Gusmão  1   2 , Lucas Garcia  3 , Mohamad A Mikati  4 , Samantha Su  4 , Laura Silveira-Moriyama  2   3   5
Affiliations
Review

Paroxysmal Genetic Movement Disorders and Epilepsy

Claudio M de Gusmão et al. Front Neurol. .

Abstract

Paroxysmal movement disorders include paroxysmal kinesigenic dyskinesia, paroxysmal non-kinesigenic dyskinesia, paroxysmal exercise-induced dyskinesia, and episodic ataxias. In recent years, there has been renewed interest and recognition of these disorders and their intersection with epilepsy, at the molecular and pathophysiological levels. In this review, we discuss how these distinct phenotypes were constructed from a historical perspective and discuss how they are currently coalescing into established genetic etiologies with extensive pleiotropy, emphasizing clinical phenotyping important for diagnosis and for interpreting results from genetic testing. We discuss insights on the pathophysiology of select disorders and describe shared mechanisms that overlap treatment principles in some of these disorders. In the near future, it is likely that a growing number of genes will be described associating movement disorders and epilepsy, in parallel with improved understanding of disease mechanisms leading to more effective treatments.

Keywords: episodic ataxia; generalized epilepsy and paroxysmal dyskinesia; infantile convulsions and choreoathetosis syndrome; paroxysmal exercise induced dyskinesia; paroxysmal kinesigenic dyskinesia; paroxysmal non-kinesigenic dyskinesia.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Abnormalities that have been observed in Na+/K+-ATPase related ion transport secondary to ATP1A3 mutations.
See this image and copyright information in PMC

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