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Review
. 2021 Apr;37(4):333-341.
doi: 10.1051/medsci/2021021. Epub 2021 Apr 9.

[Involvement of the complement cascade in severe forms of COVID-19]

[Article in French]
Nassima Chouaki Benmansour  1 , Julien Carvelli  2 , Éric Vivier  3
Affiliations
Free article
Review

[Involvement of the complement cascade in severe forms of COVID-19]

[Article in French]
Nassima Chouaki Benmansour et al. Med Sci (Paris). 2021 Apr.
Free article

Abstract
in English, French

The complement system is an essential component of the innate immune system. Its excessive activation during COVID-19 contributes to cytokine storm, disease-specific endothelial inflammation (endotheliitis) and thrombosis that comes with the disease. Targeted therapies of complement inhibition in COVID-19, in particular blocking the C5a-C5aR1 axis have to be taken into account in the establishment of potential biomarkers and development of therapeutic strategies in the most severe forms of the disease.

Title: Implication de la cascade du complément dans les formes sévères de COVID-19.

Abstract: Le système du complément est un composant essentiel du système immunitaire inné. Son activation excessive au cours de la COVID-19 participe à l’orage cytokinique, à l’inflammation endothéliale (endothélite) et aux thromboses qui accompagnent la maladie. Bloquer le complément, notamment l’axe C5a-C5aR1, par des thérapies spécifiques représente un espoir thérapeutique dans les formes les plus sévères de la maladie.

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