Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2021 Apr 1;4(4):e217939.
doi: 10.1001/jamanetworkopen.2021.7939.

Genome Analysis for Sequence Variants in SARS-CoV-2 Among Asymptomatic Individuals in a Long-term Care Facility

Baha Abdalhamid  1   2 , Peter C Iwen  1   2 , Michael R Wiley  3 , Catherine B Pratt  3 , Steven H Hinrichs  1   2
Affiliations
Observational Study

Genome Analysis for Sequence Variants in SARS-CoV-2 Among Asymptomatic Individuals in a Long-term Care Facility

Baha Abdalhamid et al. JAMA Netw Open. .

Abstract

This cohort study analyzes sequence variants in the genome of SARS-CoV-2 using viral RNA samples taken from 7 women at a long-term care facility.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr Hinrichs reported being a member of the Department of Health and Human Services Clinical Laboratory Improvement Advisory Committee. No other disclosures were reported.

Figures

Figure.
Figure.. Sequence Alignment Between the 7 SARS-CoV-2 Strains and Wuhan Strain With Amino Acid Changes
See this image and copyright information in PMC

References

    1. Korber B, Fischer WM, Gnanakaran S, et al. . Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell. 2020;182(4):812-827.e819. doi:10.1016/j.cell.2020.06.043 - DOI - PMC - PubMed
    1. Benton DJ, Wrobel AG, Xu P, et al. . Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. Nature. 2020;588(7837):327-330. doi:10.1038/s41586-020-2772-0 - DOI - PMC - PubMed
    1. Yanes-Lane M, Winters N, Fregonese F, et al. . Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: a systematic review and meta-analysis. PLoS One. 2020;15(11):e0241536. doi:10.1371/journal.pone.0241536 - DOI - PMC - PubMed
    1. Li J, Wang H, Mao L, et al. . Rapid genomic characterization of SARS-CoV-2 viruses from clinical specimens using nanopore sequencing. Sci Rep. 2020;10(1):17492. doi:10.1038/s41598-020-74656-y - DOI - PMC - PubMed
    1. Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020;367(6485):1444-1448. doi:10.1126/science.abb2762 - DOI - PMC - PubMed

Publication types