Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;134(1-2):80-82.
doi: 10.1007/s00508-021-01850-x. Epub 2021 Apr 9.

Psoas muscle index at the time of diagnosis might reflect the prognosis of classical Hodgkin's lymphoma patients

Marko Lucijanić  1   2 , Renata Huzjan Korunić  3   4 , Marija Ivić  5 , Amina Fazlić Džankić  6 , Željko Jonjić  5 , Zdravko Mitrović  5   3 , Željko Prka  5 , Mario Piršić  5 , Ozren Jakšić  5   3 , Petar Gaćina  7   8 , Josipa Vlasac Glasnović  5 , Vlatko Pejša  5   3
Affiliations

Psoas muscle index at the time of diagnosis might reflect the prognosis of classical Hodgkin's lymphoma patients

Marko Lucijanić et al. Wien Klin Wochenschr. 2022 Jan.

Abstract

We retrospectively investigated clinical and prognostic significance of psoas muscle index (PMI) calculated as total psoas muscle area at L3 vertebra level obtained from baseline computed tomography (CT) scans in 49 newly diagnosed classical Hodgkin's lymphoma (cHL) patients prior to specific treatment. Median PMI was 572.5 mm2/m2 and was significantly higher in males (P < 0.001), patients with higher body mass index (BMI, P < 0.001), absence of extranodal disease (P = 0.037), higher absolute lymphocyte count (P = 0.037), higher hemoglobin (P = 0.010) and lower lactate dehydrogenase (LDH, P = 0.050). There were no significant associations with age, disease subtype, presence of constitutional symptoms, Ann Arbor disease stage, presence of advanced disease or international prognostic score. Patients with lower PMI had significantly worse PFS (hazard ratio [HR] 4.91; P = 0.009). This phenomenon persisted in the multivariate model (HR = 5.09; P = 0.042) adjusted for International Prognostic Score (IPS) and chemotherapy type.

Keywords: Lymphoproliferative neoplasm; Prognostication; Progression; Sarcopenia; Survival.

PubMed Disclaimer

References

    1. Connors JM, Cozen W, Steidl C, et al. Hodgkin lymphoma. Nat Rev Dis Primers. 2020;6(1):61. - DOI
    1. Cirillo M, Borchmann S. An update on disease biomarkers for Hodgkin lymphoma. Expert Rev Hematol. 2020;13(5):481–8. - DOI
    1. Hutchings M, Mikhaeel NG, Fields PA, Nunan T, Timothy AR. Prognostic value of interim FDG-PET after two or three cycles of chemotherapy in Hodgkin lymphoma. Ann Oncol. 2005;16(7):1160–8. - DOI
    1. Iltar U, Sözel H, Sözel YK, et al. Prognostic impact of the psoas muscle index, a parameter of sarcopenia, in patients with diffuse large B‑cell lymphoma treated with rituximab-based chemoimmunotherapy. Leuk Lymphoma. 2020; https://doi.org/10.1080/10428194.2020.1856833 . - DOI - PubMed
    1. Lucijanic M, Galusic D, Soric E, et al. Ruxolitinib treatment improves muscle mass in patients with myelofibrosis. Ann Hematol. 2021;100(4):1105-1106. - DOI

LinkOut - more resources