Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021:2284:467-480.
doi: 10.1007/978-1-0716-1307-8_25.

Databases for RNA Editing Collections

Claudio Lo Giudice  1 , Luigi Mansi  1 , Graziano Pesole  1   2   3   4 , Ernesto Picardi  5   6   7
Affiliations

Databases for RNA Editing Collections

Claudio Lo Giudice et al. Methods Mol Biol. 2021.

Erratum in

  • Correction to: RNA Bioinformatics.
    Picardi E. Picardi E. Methods Mol Biol. 2021;2284:C1. doi: 10.1007/978-1-0716-1307-8_32. Methods Mol Biol. 2021. PMID: 34339024 No abstract available.

Abstract

A-to-I RNA editing in humans plays a relevant role since it can influence gene expression and increase proteome diversity. In addition, its deregulation has been linked to a variety of human diseases, including neurological disorders and cancer.In the last decade, massive transcriptome sequencing through the RNAseq technology has dramatically improved the investigation of RNA editing at single nucleotide resolution. Nowadays, different bioinformatics resources to discover and/or collect A-to-I events have been released. Hereafter, we initially provide an overview of the state-of-the-art RNA editing databases and, then, we focus on REDIportal, the largest collection of A-to-I events with more than 4.5 million sites from 2660 humans GTEx samples.

Keywords: A-to-I editing; Database; REDIportal; RNA editing; RNAseq; Transcriptomics.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Eisenberg E, Levanon EY (2018) A-to-I RNA editing - immune protector and transcriptome diversifier. Nat Rev Genet 19:473–490. https://doi.org/10.1038/s41576-018-0006-1 - DOI - PubMed
    1. Barak M, Levanon EY, Eisenberg E, Paz N, Rechavi G, Church GM, Mehr R (2009) Evidence for large diversity in the human transcriptome created by Alu RNA editing. Nucleic Acids Res 37:6905–6915. https://doi.org/10.1093/nar/gkp729 - DOI - PubMed - PMC
    1. Pullirsch D, Jantsch MF (2010) Proteome diversification by adenosine to inosine RNA-editing. RNA Biol 7:205–212. https://doi.org/10.4161/rna.7.2.11286 - DOI - PubMed
    1. Bahn JH, Lee J-H, Li G, Greer C, Peng G, Xiao X (2012) Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res 22:142–150. https://doi.org/10.1101/gr.124107.111 - DOI - PubMed - PMC
    1. Rosenberg BR, Hamilton CE, Mwangi MM, Dewell S, Papavasiliou FN (2011) Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3′ UTRs. Nat Struct Mol Biol 18:230–236. https://doi.org/10.1038/nsmb.1975 - DOI - PubMed - PMC

Publication types

LinkOut - more resources