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. 2021:2284:467-480.
doi: 10.1007/978-1-0716-1307-8_25.

Databases for RNA Editing Collections

Claudio Lo Giudice  1 , Luigi Mansi  1 , Graziano Pesole  1   2   3   4 , Ernesto Picardi  5   6   7
Affiliations

Databases for RNA Editing Collections

Claudio Lo Giudice et al. Methods Mol Biol. 2021.

Erratum in

  • Correction to: RNA Bioinformatics.
    Picardi E. Picardi E. Methods Mol Biol. 2021;2284:C1. doi: 10.1007/978-1-0716-1307-8_32. Methods Mol Biol. 2021. PMID: 34339024 No abstract available.

Abstract

A-to-I RNA editing in humans plays a relevant role since it can influence gene expression and increase proteome diversity. In addition, its deregulation has been linked to a variety of human diseases, including neurological disorders and cancer.In the last decade, massive transcriptome sequencing through the RNAseq technology has dramatically improved the investigation of RNA editing at single nucleotide resolution. Nowadays, different bioinformatics resources to discover and/or collect A-to-I events have been released. Hereafter, we initially provide an overview of the state-of-the-art RNA editing databases and, then, we focus on REDIportal, the largest collection of A-to-I events with more than 4.5 million sites from 2660 humans GTEx samples.

Keywords: A-to-I editing; Database; REDIportal; RNA editing; RNAseq; Transcriptomics.

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