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. 2021 Jun;44(6):1047-1053.
doi: 10.1111/pace.14241. Epub 2021 Apr 19.

Resting electrocardiographic differences in ventricular repolarization between children and young adults with congenital heart disease and those with a structurally normal heart are diminished by exercise

Utkarsh Kohli  1   2 , Hemal M Nayak  3 , Angela G Romme  4 , Hoang H Nguyen  4   5
Affiliations

Resting electrocardiographic differences in ventricular repolarization between children and young adults with congenital heart disease and those with a structurally normal heart are diminished by exercise

Utkarsh Kohli et al. Pacing Clin Electrophysiol. 2021 Jun.

Abstract

Objective: Exercise-induced repolarization changes have not been systematically evaluated in children and young adults with congenital heart disease (CHD). We carried out this study to assess the QTc responses during exercise in children and young adults (≤ 21 years) with CHD with comparison to those with structurally normal hearts.

Methods: Baseline QRS duration, calculated baseline QTc, QTc at 4 min of recovery and delta QTc was measured in 360 exercise stress tests which were performed in 360 subjects (137 stress tests in patients with CHD [CHD group] and 223 stress tests in patients with structurally normal hearts). The effects of presence of CHD and potential confounders on primary outcome measure, change in QTc (delta QTc), and secondary outcome measures (QTc at baseline and QTc at 4 min of recovery) were determined using multiple linear regression analyses.

Results: The baseline QTc and the QTc at 4 min of recovery in the CHD group was longer than patients with structurally normal hearts (respective p values = .00 and .001). No significant difference was noted in delta QTc between the CHD and structurally normal heart groups.

Conclusions: While patients with CHD had a longer QRS duration and QTc interval at baseline than those with structurally normal hearts, these differences did not persist or augment with exercise.

Keywords: congenital heart disease; exercise stress testing; ventricular repolarization.

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References

REFERENCES

    1. Koyak Z, Harris L, de Groot JR, et al. Sudden cardiac death in adult congenital heart disease. Circulation. 2012;126:1944-1954.
    1. Diller GP, Baumgartner H. Sudden cardiac death during exercise in patients with congenital heart disease: the exercise paradox and the challenge of appropriate counselling. Eur Heart J. 2016;37:627-629.
    1. Zomer AC, Vaartjes I, Uiterwaal CS, et al. Circumstances of death in adult congenital heart disease. Int J Cardiol. 2012;154:168-172.
    1. https://www.crediblemeds.org/drugsearch
    1. Engeseth K, Hodnesdal C, Grundvold I, et al. Temporal reduction in chronotropic index predicts risk of cardiovascular death among healthy middle-aged men: a 28-year follow-up study. J Am Heart Assoc. 2016;5:e004555.

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