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Review
. 2021 Jun 1;203(11):1343-1352.
doi: 10.1164/rccm.202103-0559UP.

Update in Interstitial Lung Disease 2020

Affiliations
Review

Update in Interstitial Lung Disease 2020

Anna J Podolanczuk et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Algorithm for the diagnostic evaluation of possible hypersensitivity pneumonitis (HP). Specific features are described for all steps of the algorithm in the corresponding sections of Reference . A provisional diagnosis may be adequate in patients for whom the differential diagnosis has been sufficiently narrowed such that further investigations are unlikely to alter management, when invasive testing has unacceptable risks, or when such tests are declined by the patient. *Exposure assessment includes a thorough clinical history and/or serum IgG testing against potential antigens associated with HP and/or, in centers with the appropriate expertise and experience, specific inhalational challenge testing as described in References 9, 323, 324, and 325 of Reference . **HRCT should be performed using the technique described in Table 3 in Reference and then reviewed with a thoracic radiologist. ***Transbronchial lung biopsy (TBLB) is suggested for patients with potential nonfibrotic HP (see question 4, recommendation 1 in Reference 60). #TBLC is suggested for patients with potential nonfibrotic HP, depending on local expertise (see question 5, recommendation 2 in Reference 60). ##SLB is infrequently considered in patients with nonfibrotic HP. Figure 6 refers to Figure 6 in Reference . HRCT = high-resolution computed tomography; SLB = surgical lung biopsy; TBLC = transbronchial lung cryobiopsy. Adapted by permission from Reference .

References

    1. Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, et al. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Sci Adv. 2020;6:eaba1983. - PMC - PubMed
    1. Habermann AC, Gutierrez AJ, Bui LT, Yahn SL, Winters NI, Calvi CL, et al. Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis. Sci Adv . 2020;6:eaba1972. - PMC - PubMed
    1. Carraro G, Mulay A, Yao C, Mizuno T, Konda B, Petrov M, et al. Single-cell reconstruction of human basal cell diversity in normal and idiopathic pulmonary fibrosis lungs. Am J Respir Crit Care Med . 2020;202:1540–1550. - PMC - PubMed
    1. Eickelberg O, Misharin AV, Sime PJ. Reproducible single-cell genomic research in pulmonary and critical care medicine. Am J Respir Crit Care Med . 2020;202:1495–1497. - PMC - PubMed
    1. Tsukui T, Sun K-H, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, et al. Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nat Commun . 2020;11:1920. - PMC - PubMed

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