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. 2021 Apr 22;368(6):fnab038.
doi: 10.1093/femsle/fnab038.

Short-chain fatty acid and fecal microbiota profiles are linked to fibrosis in primary biliary cholangitis

Craig Lammert  1 , Andrea S Shin  1 , Huiping Xu  2 , Christopher Hemmerich  3 , Thomas M O'Connell  4 , Naga Chalasani  1
Affiliations

Short-chain fatty acid and fecal microbiota profiles are linked to fibrosis in primary biliary cholangitis

Craig Lammert et al. FEMS Microbiol Lett. .

Abstract

The gut microbiota and metabolome could play a role in primary biliary cholangitis (PBC) progression. We aimed to assess fecal microbiota and fecal short-chain fatty acids (SCFAs) in PBC according to fibrosis. In a cross-sectional study of 23 PBC patients, fecal microbiota and SCFAs were determined using 16S rRNA sequencing and nuclear magnetic resonance spectroscopy, respectively. Fecal acetate and SCFAs were higher in advanced fibrosis. Advanced fibrosis microbiota exhibited decreased alpha diversity, increased Weisella and a distinct community composition. SCFAs correlated with individual taxa in non-advanced fibrosis. Fecal microbiota and SCFAs correspond to fibrosis in PBC.

Keywords: acetate; butyrate; metabolome; microbiome; primary biliary cirrhosis; propionate.

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Figures

Figure 1.
Figure 1.
Fecal microbiota (A) alpha diversity with Shannon diversity index, (B) alpha diversity with Faith's phylogenetic diversity index and (C) beta diversity using unweighted UniFrac distances are associated with fibrosis group.
Figure 2.
Figure 2.
Correlations between fecal acetate and relative abundance of (A)Lachnospiraceae group NK4A136 and (B)Collinsella.
See this image and copyright information in PMC

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