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Meta-Analysis
. 2021 Apr 9;22(1):14.
doi: 10.1186/s12863-021-00968-1.

Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis

Xiao-Ning Zhao #  1 , Quan Sun #  2 , You-Qin Cao  1 , Xiao Ran  3 , Yu Cao  4
Affiliations
Meta-Analysis

Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis

Xiao-Ning Zhao et al. BMC Genom Data. .

Abstract

Background: Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions.

Results: A total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5-1131 T > C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444, and 1.710, respectively. All P-values were less than 0.05.

Conclusions: Meta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.

Keywords: APO; Apolipoprotein; Gene polymorphism; Hyperlipidemia; Meta-analysis.

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Conflict of interest statement

We declare that none of the work contained in this manuscript is published in any language or currently under consideration at any other journal, and there are no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Flow diagram of the meta-analysis
Fig. 2
Fig. 2
Pooled calculated OR for the association between the APOA5–1131 T > C allele and hyperlipidemia
Fig. 3
Fig. 3
Subgroup analysis by ethnicity for the association between the APOA5–1131 T > C allele and the risk of hyperlipidemia
Fig. 4
Fig. 4
Pooled calculated OR for the association between the APOA1-75 bp allele and hyperlipidemia
Fig. 5
Fig. 5
Pooled calculated OR for the association between the APOB XbaI allele and hyperlipidemia
Fig. 6
Fig. 6
Subgroup analysis by ethnicity for the association between the APOB XbaI allele and the risk of hyperlipidemia
Fig. 7
Fig. 7
Pooled calculated OR for the association between the APOE allele and hyperlipidemia
Fig. 8
Fig. 8
Subgroup analysis by ethnicity for the association between the APOE ε2 and ε3 alleles and the risk of hyperlipidemia
Fig. 9
Fig. 9
Subgroup analysis by ethnicity for the association between the APOE ε3 and ε4 alleles and the risk of hyperlipidemia
Fig. 10
Fig. 10
Begg’s funnel plot for the APOE ε4 allele
See this image and copyright information in PMC

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