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. 2021 Dec;29(12):1058-1061.
doi: 10.1016/j.tim.2021.03.007. Epub 2021 Apr 6.

Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens

Pramod K Jangir  1 , Lois Ogunlana  2 , R Craig MacLean  2
Affiliations

Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens

Pramod K Jangir et al. Trends Microbiol. 2021 Dec.

Abstract

Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.

Keywords: antibiotic resistance; antimicrobial peptide resistance; bacterial evolution.

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Conflict of interest statement

Declaration of interests There are no interests to declare.

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