Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul-Sep;44(3):336-340.
doi: 10.1016/j.htct.2020.11.009. Epub 2021 Jan 27.

Hemoglobin S identification in blood donors: A cross section of prevalence

Fernanda Lima Kroger  1 , Ianka Cristina Ernesto  2 , Marina Schuffner Silva  2 , Olivia Franco Dos Santos  3 , Renato Lourenço de Medeiros  4 , Daniela de Oliveira Werneck Rodrigues  5
Affiliations

Hemoglobin S identification in blood donors: A cross section of prevalence

Fernanda Lima Kroger et al. Hematol Transfus Cell Ther. 2022 Jul-Sep.

Abstract

Introduction: In Brazil, the sickle cell trait (SCT) has an average prevalence of 4% in the general population and 6-10% among Afro-descendants. Although SCT is highly prevalent, a large segment of the population ignores their status. The Therapeutic Guidelines prohibit the transfusion of SCT red blood cells into patients with hemoglobin disorders or severe acidosis and newborns.

Methods: This was a cross-sectional study with data from 37,310 blood donation candidates. The study included only eligible first-time donors qualified to be tested for the presence of hemoglobin S (HbS) at the Fundação Hemominas Juiz de Fora, Brazil. The variables studied were gender, skin color, age, type of donation, place of birth, blood type, result of the solubility test for hemoglobin S (HbST) and hemoglobin electrophoresis (HbEF). Statistical analysis was performed using the Q square test and the Kappa index of agreement for comparing biochemical methods. This project was approved by the National Research Ethics Committee.

Results: The analysis of first-time donor data showed that 7166 were considered eligible. A total of 127 of the 7166 donors were carriers of SCT (1.77%). Among the blood donors, 73.23% were from the local area. The HbST and HbEF were found to be 100% in concordance. Sensitivity was not tested in the present study.

Conclusions: The HbST is highly specific for identifying the HbS, but sensitivity was not tested in this study. The screening of blood donors for abnormal hemoglobins is useful, helping to detect and counsel heterozygous people. The study seeks to identify the prevalence of SCT in a region of Brazil.

Keywords: Blood donors; Red blood cells; Sickle cell anaemia; Sickle cell trait.

PubMed Disclaimer

References

    1. Cançado R.D., Jesus J.A. The sickle cell disease in Brazil. Rev Bras Hematol Hemoter. 2007;29(3):203–206.
    1. Brasil. Ministério da Saúde. Portaria no 822 de 06 de junho de 2001.Estabelece o Programa de Triagem Neonatal no Brasil.
    1. Brasil. Ministério da Saúde. Portaria no 153 de 14 de junho de 2004. Aprova as normas técnicas para coleta, processamento e transfusão de sangue, componentes e derivados e dá outras providências. Available from: http://bvsms.saude.gov.br. [cited 2020 June 6].
    1. Brasil. Ministério da Saúde. Portaria no 158 de 4 de fevereiro de 2016. Resolução RDC Estabele normas para hemoterapia. Available from: http://www.anvisa.gov.br. [cited 2019 July 18].
    1. Fundação Hemominas http://www.hemominas.mg.gov.br. Fundação Hemominas: mais de três décadas a serviço dos mineiros. [cited 2019 August 21]. Available from: http://www.hemominas.mg.gov.br/banco-de-noticias/29-institucional/2585-f....

LinkOut - more resources