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Comment
. 2021 Apr 10;6(1):150.
doi: 10.1038/s41392-021-00577-5.

The anti-inflammatory astrocyte revealed: the role of the microbiome in shaping brain defences

Alexei Verkhratsky  1   2   3   4 , Peter Illes  5   6 , Yong Tang  5 , Alexey Semyanov  7   8   9
Affiliations
Comment

The anti-inflammatory astrocyte revealed: the role of the microbiome in shaping brain defences

Alexei Verkhratsky et al. Signal Transduct Target Ther. .
No abstract available

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Figures

Fig. 1
Fig. 1
Anti-inflammatory astrocytes. The subpopulation of anti-inflammatory astrocytes is present in the spinal cord of mice and possibly of humans. These astrocytes specifically express the lysosomal associated protein 1 (LAMP1) and the death receptor ligand TRAIL; the latter after being released activate death receptors on T lymphocytes instigating their apoptosis. Expression of TRAIL in astrocytes is controlled by IFN-γ secreted by meningeal natural killer cells; IFN-γ reaches astrocytic endfeet through subarachnoid cerebrospinal fluid. The IFN-γ natural killer cells are, in their turn, under control from systemic factors including the gut microbiome; depletion of the latter substantially reduces the number of IFN-γ secreting natural killer cells
See this image and copyright information in PMC

Comment on

  • Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes.
    Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Sanmarco LM, et al. Nature. 2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4. Epub 2021 Jan 6. Nature. 2021. PMID: 33408417 Free PMC article.

References

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