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Comment
. 2021 Apr 10;6(1):151.
doi: 10.1038/s41392-021-00592-6.

SARS-CoV-2 variants: a new challenge to convalescent serum and mRNA vaccine neutralization efficiency

Maochen Li #  1 , Fuxing Lou #  1 , Huahao Fan  2
Affiliations
Comment

SARS-CoV-2 variants: a new challenge to convalescent serum and mRNA vaccine neutralization efficiency

Maochen Li et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A schematic illustration of SARS-CoV-2 S protein sequence, prevalent mutations in current circulating SARS-CoV-2 variants, and the neutralization efficiency change of two mRNA vaccines—vaccine AZD1222 and vaccine BNT162b2. a RBM sequence (amino acid 437–508) containing N439K, E484K, and N501Y is a highly variable region, and SARS-CoV-2 spike protein mutations of three major circulating variants B.1.1.7, B.1.351, and P.1 are displayed, which can be tracked online (https://covariants.org/, https://cov-lineages.org/). b The neutralization efficiency of two major vaccines—vaccine AZD1222 and vaccine BNT162b2 to major circulating variants and potentially important variants of SARS-CoV-2 are exhibited. The neutralizing activity of the vaccine sera against different variants are shown in different colors from light red (no sufficient decrease), lycopene (decrease between 1.5-fold and 2.5-fold), to wine red (decrease more than 2.5-fold)
See this image and copyright information in PMC

Comment on

  • Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.
    Supasa P, Zhou D, Dejnirattisai W, Liu C, Mentzer AJ, Ginn HM, Zhao Y, Duyvesteyn HME, Nutalai R, Tuekprakhon A, Wang B, Paesen GC, Slon-Campos J, López-Camacho C, Hallis B, Coombes N, Bewley KR, Charlton S, Walter TS, Barnes E, Dunachie SJ, Skelly D, Lumley SF, Baker N, Shaik I, Humphries HE, Godwin K, Gent N, Sienkiewicz A, Dold C, Levin R, Dong T, Pollard AJ, Knight JC, Klenerman P, Crook D, Lambe T, Clutterbuck E, Bibi S, Flaxman A, Bittaye M, Belij-Rammerstorfer S, Gilbert S, Hall DR, Williams MA, Paterson NG, James W, Carroll MW, Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Supasa P, et al. Cell. 2021 Apr 15;184(8):2201-2211.e7. doi: 10.1016/j.cell.2021.02.033. Epub 2021 Feb 18. Cell. 2021. PMID: 33743891 Free PMC article.

References

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