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. 2021 Sep;28(5):1051-1061.
doi: 10.1007/s12282-021-01240-1. Epub 2021 Apr 11.

Long-term outcomes of oligometastatic breast cancer patients treated with curative intent: an updated report

Eijiro Nagasaki  1 , Rei Kudo  2 , Miho Tamura  3 , Kazumi Hayashi  3 , Tadashi Uwagawa  3 , Yoshikazu Kijima  4 , Hiroko Nogi  2 , Hiroshi Takeyama  2 , Masafumi Suzuki  5 , Masako Nishikawa  6 , Shingo Yano  3 , Tadashi Kobayashi  3
Affiliations

Long-term outcomes of oligometastatic breast cancer patients treated with curative intent: an updated report

Eijiro Nagasaki et al. Breast Cancer. 2021 Sep.

Abstract

Background: Oligometastatic breast cancer (OMBC) is characterized by limited metastatic tumor numbers and sites. We have reported a 20-year overall survival (OS) rate and relapse-free rate (RFR) of 34.1% and 27.4%, respectively, in a retrospective analysis of OMBC patients treated with curative intent including a multidisciplinary approach. Metastatic breast cancer (MBC) is generally incurable; however, OMBC might be a potentially curable subset. The previous analysis included isolated locoregional recurrence (ILRR) cases, which differs from distant metastasis in treatment strategies. Therefore, in this study, we excluded ILRR cases and provided an update on clinical outcomes. We also performed a detailed subgroup analysis of OMBC patients by introducing new prognostic variables.

Methods: Data of 73 OMBC patients, including 10 ILRR cases, treated in our institution between 1980 and 2010 were retrospectively analyzed. OMBC was defined as the presence of metastatic lesions in 1-2 organs, < 5 lesions per metastasized organ, and lesion diameter < 5 cm.

Results: The median follow-up duration was 151 (range 12-350) months. Twenty-eight (44%) patients received local therapy. Excluding ILRR cases, the OS rates were 28.3% and 18.9% and RFRs were 26.7% at 20 and 25 years, respectively. In multivariate analysis, single-organ involvement and three or fewer metastatic lesions per organ were associated with a longer progression-free and relapse-free interval (RFI).

Conclusions: Relapse-free interval reached a plateau after 20 years at approximately 25% probability. Patients with long-term survival without disease relapse are considered cured. Curative-intent therapy should be considered for OMBC patients, especially those with low tumor volume.

Keywords: Breast cancer; Multidisciplinary therapy; Oligometastases; Oligometastatic breast cancer.

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