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Review
. 2021 Mar 24:15:653367.
doi: 10.3389/fncel.2021.653367. eCollection 2021.

Mesenchymal Stem Cells Transplantation in Intracerebral Hemorrhage: Application and Challenges

Yu-Hua Gong  1 , Shi-Lei Hao  1 , Bo-Chu Wang  1
Affiliations
Review

Mesenchymal Stem Cells Transplantation in Intracerebral Hemorrhage: Application and Challenges

Yu-Hua Gong et al. Front Cell Neurosci. .

Abstract

Intracerebral hemorrhage (ICH) is one of the leading causes of death and long-term disability worldwide. Mesenchymal stem cell (MSC) therapies have demonstrated improved outcomes for treating ICH-induced neuronal defects, and the neural network reconstruction and neurological function recovery were enhanced in rodent ICH models through the mechanisms of neurogenesis, angiogenesis, anti-inflammation, and anti-apoptosis. However, many key issues associated with the survival, differentiation, and safety of grafted MSCs after ICH remain to be resolved, which hinder the clinical translation of MSC therapy. Herein, we reviewed an overview of the research status of MSC transplantation after ICH in different species including rodents, swine, monkey, and human, and the challenges for MSC-mediated ICH recovery from pathological microenvironment have been summarized. Furthermore, some efficient strategies for the outcome improvement of MSC transplantation were proposed.

Keywords: different species; intracerebral hemorrhage; mesenchymal stem cells; optimizing strategy; pathological microenvironment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
A summarization of the challenges of ICH microenvironments on MSC transplantation.
See this image and copyright information in PMC

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