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. 2021 Mar 15;13(3):1750-1756.
eCollection 2021.

The immunomodulatory effects of vitamin D drops in children with recurrent respiratory tract infections

Jianqiu Xiao  1 , Wei He  1
Affiliations

The immunomodulatory effects of vitamin D drops in children with recurrent respiratory tract infections

Jianqiu Xiao et al. Am J Transl Res. .

Abstract

Objective: To investigate the effects of vitamin D drops on immune function in children with recurrent respiratory tract infections (RRTI).

Methods: The clinical data of 119 children with RRTI in our hospital were retrospectively retrieved, and they were divided into group A (n=59, receiving routine treatment) and group B (n=60, receiving vitamin D drops) based on their treatment modality. The clinical efficacy, symptom disappearance time, immune function index, insulin-like growth factor (IGF-1), 25-hydroxyvitamin D3 [25-(OH)D3], serum y-interferon (INF-y), and the number of episodes of respiratory tract infections were compared between the two groups.

Results: The total effective rate of treatment in group B was 96.67%, which was significantly higher than 71.19% in group A (P<0.05). Children in group B had shorter time to disappearance of lung rales, cough, and fever than group A (P<0.05). Group B had higher IgA, IgG, and IgM levels, higher CD4+, CD3+ levels and lower CD8+ levels as well as higher IGF-1, 25-(OH)D3, INF-y levels, and fewer respiratory infections after treatment than group A (P<0.05).

Conclusion: Vitamin D drops are effective in the treatment of children with RRTI, which is beneficial to the improvement of clinical symptoms and immune function.

Keywords: Recurrent; children; immune function; respiratory tract infections; vitamin D drops.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of the disappearance time of symptoms between the two groups. A. Disappearance time of fever; B. The time of disappearance of cough; C. The disappearance time of lung rales. *P<0.05, compared with group A.
Figure 2
Figure 2
Comparison of immunoglobulin levels between the two groups. A: IgA levels; B: IgM levels; C: IgG levels. *P<0.05, compared with group A.
Figure 3
Figure 3
Comparison of T-lymphocyte subsets between the two groups. A: CD4+ levels; B: CD8+ levels; C: CD3+ levels. *P<0.05, compared with group A.
Figure 4
Figure 4
Comparison of clinical indices between the two groups. A: INF-y levels; B: 25-(OH)D3 levels; C: IGF-1 levels. *P<0.05, compared with group A.
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