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Review
. 2021;8(2):140-150.
doi: 10.1007/s40472-021-00323-4. Epub 2021 Apr 6.

Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality

Basil S Nasir  1 , Jacob Klapper  2 , Matthew Hartwig  2
Affiliations
Review

Lung Transplant from ECMO: Current Results and Predictors of Post-transplant Mortality

Basil S Nasir et al. Curr Transplant Rep. 2021.

Abstract

Purpose of review: We examined data from the last 5 years describing extracorporeal life support (ECLS) as a bridge to lung transplantation. We assessed predictors of survival to transplantation and post-transplant mortality.

Recent findings: The number of lung transplants performed worldwide is increasing. This is accompanied by an increase in the type of patients being transplanted, including sicker patients with more advanced disease. Consequently, there is an increase in the need for bridging strategies, with varying success. Several predictors of failure have been identified. Major risk factors include retransplantation, other organ dysfunction, and deconditioning.

Summary: ECLS is a risky strategy but necessary for patients who would otherwise die if not bridged to transplantation. The presence of predictors for failure is not a contraindication for bridging. However, major risk factors should be approached cautiously. Other, more minor risk factors may be considered acceptable. More importantly, the strategy should be individualized for each patient to achieve the best possible outcomes.

Keywords: Bridge to transplant; Extracorporeal life support (ECLS); Extracorporeal membrane oxygenation (ECMO); Lung transplantation.

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Figures

Fig. 1
Fig. 1
Algorithm for the management of patients awaiting lung transplant who require ECMO BTT
See this image and copyright information in PMC

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