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Case Reports
. 2021 Mar 25:11:638395.
doi: 10.3389/fonc.2021.638395. eCollection 2021.

Case Report: Cutaneous Squamous Cell Carcinoma Arising From the Ulcer of the Lesions of Dupuytren's Disease on the Palm

Qingmiao Sun  1 , Bin Fu  2 , Sheng Li  1 , Hong Fang  1 , Jianjun Qiao  1
Affiliations
Case Reports

Case Report: Cutaneous Squamous Cell Carcinoma Arising From the Ulcer of the Lesions of Dupuytren's Disease on the Palm

Qingmiao Sun et al. Front Oncol. .

Abstract

Dupuytren's disease is a benign fibromatosis that mainly involves the fascia of the palm and digits. The relationship between Dupuytren's disease and the evolution of cutaneous squamous cell carcinoma is still unclear. Here we report the case of a 52-year-old female with squamous cell carcinoma arising from the ulcer of the lesions of Dupuytren's disease on the left palm. To our knowledge, this is the first reported case in the English literature of squamous cell carcinoma on the palm of someone with Dupuytren's disease.

Keywords: Dupuytren’s disease; palm; skin cancer; squamous cell carcinoma; surgical excision.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Clinical features of the hand lesions. (A, B) Contracture deformity of both hands was evident, and an ulcer was detected on the flexor side of the 5th metacarpophalangeal joint of the left hand.
Figure 2
Figure 2
Histopathology of the hand lesion. HE staining of the tissue (panel A was from the edge of the ulcer, panel B was from the ulcer) revealed atypical squamous cell proliferation and horn pearls in the dermis (H&E×100, ×10). Immunohistochemical staining of the biopsy specimen showed (C, D) the squamous cells were positive for pan cytokeratin and negative for vimentin (×100).
Figure 3
Figure 3
Timeline of the disease’s development.
See this image and copyright information in PMC

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